Angiotensin Type 2 Receptor Stimulation Increases Renal Function in Female, but Not Male, Spontaneously Hypertensive Rats

Lucinda M. Hilliard; Charis L. E. Chow; Katrina M. Mirabito; U. Muscha Steckelings; Thomas Unger; Robert E. Widdop; Kate M. Denton

doi:10.1161/HYPERTENSIONAHA.113.02809

Angiotensin Type 2 Receptor Stimulation Increases Renal Function in Female, but Not Male, Spontaneously Hypertensive Rats

Lucinda M. Hilliard
, Charis L. E. Chow
, Katrina M. Mirabito
, U. Muscha Steckelings
, Thomas Unger
, Robert E. Widdop
, Kate M. Denton^*

^*Corresponding author for this work

Bedrijfsbureau CARIM

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Accumulating evidence suggests that the protective pathways of the renin-angiotensin system are enhanced in women, including the angiotensin type 2 receptor (AT(2)R), which mediates vasodilatory and natriuretic effects. To provide insight into the sex-specific ability of pharmacological AT(2)R stimulation to modulate renal function in hypertension, we examined the influence of the AT(2)R agonist, compound 21 (100-300 ng/kg per minute), on renal function in 18- to 19-week-old anesthetized male and female spontaneously hypertensive rats. AT(2)R stimulation significantly increased renal blood flow in female hypertensive rats (P-Treatment

Original language	English
Pages (from-to)	378–383
Number of pages	6
Journal	Hypertension
Volume	64
Issue number	2
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.113.02809
Publication status	Published - Aug 2014

Keywords

hypertension
natriuresis
receptor, angiotensin, type 2
renal circulation
renin-angiotensin system
sex characteristics

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10.1161/HYPERTENSIONAHA.113.02809

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title = "Angiotensin Type 2 Receptor Stimulation Increases Renal Function in Female, but Not Male, Spontaneously Hypertensive Rats",

abstract = "Accumulating evidence suggests that the protective pathways of the renin-angiotensin system are enhanced in women, including the angiotensin type 2 receptor (AT(2)R), which mediates vasodilatory and natriuretic effects. To provide insight into the sex-specific ability of pharmacological AT(2)R stimulation to modulate renal function in hypertension, we examined the influence of the AT(2)R agonist, compound 21 (100-300 ng/kg per minute), on renal function in 18- to 19-week-old anesthetized male and female spontaneously hypertensive rats. AT(2)R stimulation significantly increased renal blood flow in female hypertensive rats (P-Treatment ",

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author = "Hilliard, \{Lucinda M.\} and Chow, \{Charis L. E.\} and Mirabito, \{Katrina M.\} and Steckelings, \{U. Muscha\} and Thomas Unger and Widdop, \{Robert E.\} and Denton, \{Kate M.\}",

year = "2014",

month = aug,

doi = "10.1161/HYPERTENSIONAHA.113.02809",

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AU - Steckelings, U. Muscha

AU - Unger, Thomas

AU - Widdop, Robert E.

AU - Denton, Kate M.

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KW - hypertension

KW - natriuresis

KW - receptor, angiotensin, type 2

KW - renal circulation

KW - renin-angiotensin system

KW - sex characteristics

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DO - 10.1161/HYPERTENSIONAHA.113.02809

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JO - Hypertension

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ER -

Angiotensin Type 2 Receptor Stimulation Increases Renal Function in Female, but Not Male, Spontaneously Hypertensive Rats

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Keywords

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