Angiotensin Type 2 Receptor Stimulation Increases Renal Function in Female, but Not Male, Spontaneously Hypertensive Rats

Lucinda M. Hilliard; Charis L. E. Chow; Katrina M. Mirabito; U. Muscha Steckelings; Thomas Unger; Robert E. Widdop; Kate M. Denton

doi:10.1161/HYPERTENSIONAHA.113.02809

Angiotensin Type 2 Receptor Stimulation Increases Renal Function in Female, but Not Male, Spontaneously Hypertensive Rats

Lucinda M. Hilliard, Charis L. E. Chow, Katrina M. Mirabito, U. Muscha Steckelings, Thomas Unger, Robert E. Widdop, Kate M. Denton^*

^*Corresponding author for this work

Bedrijfsbureau CARIM

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Accumulating evidence suggests that the protective pathways of the renin-angiotensin system are enhanced in women, including the angiotensin type 2 receptor (AT(2)R), which mediates vasodilatory and natriuretic effects. To provide insight into the sex-specific ability of pharmacological AT(2)R stimulation to modulate renal function in hypertension, we examined the influence of the AT(2)R agonist, compound 21 (100-300 ng/kg per minute), on renal function in 18- to 19-week-old anesthetized male and female spontaneously hypertensive rats. AT(2)R stimulation significantly increased renal blood flow in female hypertensive rats (P-Treatment

Original language	English
Pages (from-to)	378–383
Journal	Hypertension
Volume	64
Issue number	2
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.113.02809
Publication status	Published - Aug 2014

Keywords

hypertension
natriuresis
receptor, angiotensin, type 2
renal circulation
renin-angiotensin system
sex characteristics

Access to Document

10.1161/HYPERTENSIONAHA.113.02809

Cite this

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title = "Angiotensin Type 2 Receptor Stimulation Increases Renal Function in Female, but Not Male, Spontaneously Hypertensive Rats",

abstract = "Accumulating evidence suggests that the protective pathways of the renin-angiotensin system are enhanced in women, including the angiotensin type 2 receptor (AT(2)R), which mediates vasodilatory and natriuretic effects. To provide insight into the sex-specific ability of pharmacological AT(2)R stimulation to modulate renal function in hypertension, we examined the influence of the AT(2)R agonist, compound 21 (100-300 ng/kg per minute), on renal function in 18- to 19-week-old anesthetized male and female spontaneously hypertensive rats. AT(2)R stimulation significantly increased renal blood flow in female hypertensive rats (P-Treatment ",

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AU - Steckelings, U. Muscha

AU - Unger, Thomas

AU - Widdop, Robert E.

AU - Denton, Kate M.

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KW - hypertension

KW - natriuresis

KW - receptor, angiotensin, type 2

KW - renal circulation

KW - renin-angiotensin system

KW - sex characteristics

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