Angiotensin Type 2 Receptor Stimulation Increases Renal Function in Female, but Not Male, Spontaneously Hypertensive Rats

Lucinda M. Hilliard, Charis L. E. Chow, Katrina M. Mirabito, U. Muscha Steckelings, Thomas Unger, Robert E. Widdop, Kate M. Denton*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

36 Citations (Web of Science)

Abstract

Accumulating evidence suggests that the protective pathways of the renin-angiotensin system are enhanced in women, including the angiotensin type 2 receptor (AT(2)R), which mediates vasodilatory and natriuretic effects. To provide insight into the sex-specific ability of pharmacological AT(2)R stimulation to modulate renal function in hypertension, we examined the influence of the AT(2)R agonist, compound 21 (100-300 ng/kg per minute), on renal function in 18- to 19-week-old anesthetized male and female spontaneously hypertensive rats. AT(2)R stimulation significantly increased renal blood flow in female hypertensive rats (P-Treatment
Original languageEnglish
Pages (from-to)378-+
JournalHypertension
Volume64
Issue number2
DOIs
Publication statusPublished - Aug 2014

Keywords

  • hypertension
  • natriuresis
  • receptor, angiotensin, type 2
  • renal circulation
  • renin-angiotensin system
  • sex characteristics

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