TY - JOUR
T1 - Angiotensin II: a hormone that affects lipid metabolism in adipose tissue.
AU - Goossens, G.H.
AU - Blaak, E.E.
AU - Arner, P.
AU - Saris, W.H.
AU - van Baak, M.A.
PY - 2007/1/1
Y1 - 2007/1/1
N2 - Background:Alterations in adipose tissue lipolysis may contribute to the pathophysiology of obesity and insulin resistance. We examined the effects of angiotensin II (Ang II) on abdominal subcutaneous adipose tissue lipolysis in humans.Methods and results:First, adipocytes obtained from nine normal weight and seven obese subjects were stimulated with Ang II (10(-14)-10(-6) M). Glycerol concentration in the medium, used as an indicator of adipocyte lipolysis, was significantly reduced ( approximately 20%) after Ang II stimulation in adipocytes from normal weight (P=0.04) and obese subjects (P<0.001). Based on these observations, adipocytes of seven additional obese subjects were stimulated with lower doses of Ang II (10(-17)-10(-6) M) in the presence and absence of Ang II type 1 (AT(1)) receptor blockade. Lipolysis was dose dependently inhibited by approximately 20 to 25% after Ang II stimulation (P=0.001). AT(1) receptor blockade completely abolished the Ang II-induced effects (P=0.35).Conclusion:Ang II directly inhibits abdominal subcutaneous adipocyte lipolysis in normal weight and obese subjects via the AT(1) receptor.International Journal of Obesity advance online publication, 16 May 2006; doi:10.1038/sj.ijo.0803388
AB - Background:Alterations in adipose tissue lipolysis may contribute to the pathophysiology of obesity and insulin resistance. We examined the effects of angiotensin II (Ang II) on abdominal subcutaneous adipose tissue lipolysis in humans.Methods and results:First, adipocytes obtained from nine normal weight and seven obese subjects were stimulated with Ang II (10(-14)-10(-6) M). Glycerol concentration in the medium, used as an indicator of adipocyte lipolysis, was significantly reduced ( approximately 20%) after Ang II stimulation in adipocytes from normal weight (P=0.04) and obese subjects (P<0.001). Based on these observations, adipocytes of seven additional obese subjects were stimulated with lower doses of Ang II (10(-17)-10(-6) M) in the presence and absence of Ang II type 1 (AT(1)) receptor blockade. Lipolysis was dose dependently inhibited by approximately 20 to 25% after Ang II stimulation (P=0.001). AT(1) receptor blockade completely abolished the Ang II-induced effects (P=0.35).Conclusion:Ang II directly inhibits abdominal subcutaneous adipocyte lipolysis in normal weight and obese subjects via the AT(1) receptor.International Journal of Obesity advance online publication, 16 May 2006; doi:10.1038/sj.ijo.0803388
U2 - 10.1038/sj.ijo.0803388
DO - 10.1038/sj.ijo.0803388
M3 - Article
C2 - 16703000
SN - 0307-0565
VL - 31
SP - 382
EP - 384
JO - International Journal of Obesity
JF - International Journal of Obesity
IS - 2
ER -