TY - JOUR
T1 - Angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers and the risk of developing rheumatoid arthritis in antihypertensive drug users
AU - de Jong, Hilda J. I.
AU - Vandebriel, Rob J.
AU - Saldi, Siti R. F.
AU - van Dijk, Liset
AU - van Loveren, Henk
AU - Tervaert, Jan Willem Cohen
AU - Klungel, Olaf H.
PY - 2012/8
Y1 - 2012/8
N2 - Purpose Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) are effective in the treatment of cardiovascular disease. Next to effects on hypertension and cardiac function, these drugs have anti-inflammatory and immunomodulating properties which may either facilitate or protect against the development of autoimmunity, potentially resulting in autoimmune diseases. Therefore, we determined in the current study the association between ACE inhibitor and ARB use and incident rheumatoid arthritis (RA). Methods A matched casecontrol study was conducted among patients treated with antihypertensive drugs using the Netherlands Information Network of General Practice (LINH) database in 20012006. Cases were patients with a first-time diagnosis of RA. Each case was matched to five controls for age, sex, and index date, which was selected 1 year before the first diagnosis of RA. ACE inhibitor and ARB exposure was considered to be any prescription issued in the period before index date. Logistic regression analysis was used to estimate odds ratios (ORs) and their 95% confidence intervals (CI). Results Our study included 211 cases and 667 matched controls. After controlling for potential confounders, ever use of ACE inhibitors or ARBs was not associated with incident RA (adjusted ORs [95%CI], 0.99 [0.551.79] and 1.02 [0.671.56], respectively). The adjusted ORs (95%CI) for current and past use of ACE inhibitors were 1.18 (0.751.85) and 0.61 (0.281.35). For current and past use of ARBs, these adjusted ORs (95%CI) were 1.40 (0.802.45) and 0.29 (0.051.67), respectively. No duration and doseeffect relationship was observed. Conclusions ACE inhibitor or ARB use is not associated with incident RA.
AB - Purpose Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) are effective in the treatment of cardiovascular disease. Next to effects on hypertension and cardiac function, these drugs have anti-inflammatory and immunomodulating properties which may either facilitate or protect against the development of autoimmunity, potentially resulting in autoimmune diseases. Therefore, we determined in the current study the association between ACE inhibitor and ARB use and incident rheumatoid arthritis (RA). Methods A matched casecontrol study was conducted among patients treated with antihypertensive drugs using the Netherlands Information Network of General Practice (LINH) database in 20012006. Cases were patients with a first-time diagnosis of RA. Each case was matched to five controls for age, sex, and index date, which was selected 1 year before the first diagnosis of RA. ACE inhibitor and ARB exposure was considered to be any prescription issued in the period before index date. Logistic regression analysis was used to estimate odds ratios (ORs) and their 95% confidence intervals (CI). Results Our study included 211 cases and 667 matched controls. After controlling for potential confounders, ever use of ACE inhibitors or ARBs was not associated with incident RA (adjusted ORs [95%CI], 0.99 [0.551.79] and 1.02 [0.671.56], respectively). The adjusted ORs (95%CI) for current and past use of ACE inhibitors were 1.18 (0.751.85) and 0.61 (0.281.35). For current and past use of ARBs, these adjusted ORs (95%CI) were 1.40 (0.802.45) and 0.29 (0.051.67), respectively. No duration and doseeffect relationship was observed. Conclusions ACE inhibitor or ARB use is not associated with incident RA.
KW - angiotensin-converting enzyme inhibitor
KW - angiotensin II receptor blocker
KW - rheumatoid arthritis
KW - autoimmune
KW - immunomodulation
KW - case-control study
KW - pharmacoepidemiology
U2 - 10.1002/pds.3291
DO - 10.1002/pds.3291
M3 - Article
C2 - 22674737
SN - 1053-8569
VL - 21
SP - 835
EP - 843
JO - Pharmacoepidemiology and Drug Safety
JF - Pharmacoepidemiology and Drug Safety
IS - 8
ER -