Anaplastic Large Cell Lymphoma in the breast in women with breast implants: a multidisciplinary approach to answer epidemiological, clinical and biological questions

Research output: ThesisDoctoral ThesisExternal prepared

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This dissertation studied the risks and risk factors of Breast Implant Associated Anaplastic Large Cell T-cell Lymphoma (BIA-ALCL). This is a rare type of lymphoma that occurs in the fluid or capsule surrounding a breast prosthesis. In the study, the authors highlight how many women in the Netherlands have a breast prosthesis (1 in 30) and what the risk is of BIA-ALCL: by the time a woman with a breast prosthesis reaches the age of 75, the risk is 1 in 7,000. This study also confirms the great importance of breast prosthesis registries for monitoring insights into prosthesis-related complications. In addition, genetic research has shown that BIA-ALCL shows specific DNA changes, and thus distinguishes itself as a new disease entity. The researchers call for better quality international research to identify the origins and risk factors.
Original languageEnglish
Awarding Institution
  • Maastricht University
  • van der Hulst, Rene, Supervisor
  • de Jong, D., Supervisor, External person
  • van Leeuwen, F. E., Supervisor, External person
  • Rakhorst, Hinne A., Co-Supervisor, External person
Award date10 Dec 2021
Place of PublicationMaastricht
Print ISBNs9789464234763
Publication statusPublished - 2021


  • breast prostheses
  • Breast implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL)
  • epidemiology
  • risks

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