TY - JOUR
T1 - Analysis of the relationship between abdominal aortic calcification and frailty in the middle-aged and older US population
AU - Rehemuding, Rena
AU - Kadier, Kaisaierjiang
AU - Peng, Xinliang
AU - Liu, Pengfei
AU - Dilixiati, Diliyaer
AU - Ainiwaer, Aikeliyaer
AU - Liu, Xiaozhu
AU - Liu, Xiangtao
AU - Ma, Xiang
N1 - Publisher Copyright:
© 2025 The Author(s)
PY - 2025/3/1
Y1 - 2025/3/1
N2 - Background and Objective: Abdominal aortic calcification (AAC) is a marker of cardiovascular disease and is associated with increased mortality in middle-aged and older populations. However, its relationship with frailty remains unclear. Methods: Data were obtained from the 2013–2014 National Health and Nutrition Examination Survey. AAC was quantified using the Kauppila scoring system based on dual-energy X-ray absorptiometry. Frailty was assessed using the frailty index. Multivariable logistic regression models examined the association between AAC and frailty. Results: A total of 2987 adults aged =40 years were included. Compared to individuals with an AAC-8 score of 0, low-risk (AAC-8 score = 1–2; OR: 1.24; 95 % CI, 1.00–1.53) and high-risk AAC (AAC-8 score = 3; OR: 1.83; 95 % CI, 1.03–3.23) were associated with higher odds of frailty. Similarly, mild to moderate AAC (0 < AAC-24 score = 6; OR: 1.26; 95 % CI, 1.03–1.54) and severe AAC (AAC-24 score > 6; OR: 1.79; 95 % CI, 1.07–2.99) showed positive associations with frailty. Conclusions: Among middle-aged and older populations in the United States, there exists a positive correlation between AAC and frailty. Our findings suggest that the AAC score holds promise as a valuable tool for the early identification of frailty.
AB - Background and Objective: Abdominal aortic calcification (AAC) is a marker of cardiovascular disease and is associated with increased mortality in middle-aged and older populations. However, its relationship with frailty remains unclear. Methods: Data were obtained from the 2013–2014 National Health and Nutrition Examination Survey. AAC was quantified using the Kauppila scoring system based on dual-energy X-ray absorptiometry. Frailty was assessed using the frailty index. Multivariable logistic regression models examined the association between AAC and frailty. Results: A total of 2987 adults aged =40 years were included. Compared to individuals with an AAC-8 score of 0, low-risk (AAC-8 score = 1–2; OR: 1.24; 95 % CI, 1.00–1.53) and high-risk AAC (AAC-8 score = 3; OR: 1.83; 95 % CI, 1.03–3.23) were associated with higher odds of frailty. Similarly, mild to moderate AAC (0 < AAC-24 score = 6; OR: 1.26; 95 % CI, 1.03–1.54) and severe AAC (AAC-24 score > 6; OR: 1.79; 95 % CI, 1.07–2.99) showed positive associations with frailty. Conclusions: Among middle-aged and older populations in the United States, there exists a positive correlation between AAC and frailty. Our findings suggest that the AAC score holds promise as a valuable tool for the early identification of frailty.
KW - Abdominal aortic calcification
KW - Frailty
KW - National Health and nutrition examination survey
KW - Population health
U2 - 10.1016/j.pmedr.2025.102994
DO - 10.1016/j.pmedr.2025.102994
M3 - Article
SN - 2211-3355
VL - 51
JO - Preventive Medicine Reports
JF - Preventive Medicine Reports
M1 - 102994
ER -