Analysis of Proton-Density Bias Corrections Based on T-1 Measurement for Robust Quantification of Water Content in the Brain at 3 Tesla

Zaheer Abbas, Vincent Gras, Klaus Moellenhoff, Fabian Keil, Ana-Maria Oros-Peusquens, Nadim J. Shah*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

42 Citations (Web of Science)


Purpose Estimating tissue water content using high field MRI, such as 3 Tesla (T), is challenging due to the difficulty in dissociating the radio frequency inhomogeneity pattern from the signal arising from tissue intrinsic proton density (PD) variations. To overcome this problem the longitudinal relaxation time T-1 can be combined with an initial guess of the PD to yield the desired PD bias correction. However, it is necessary to know whether T-1 effects, i.e., any effect contributing to T-1 while being independent of tissue hydration, influence the estimated correction. MethodsTwenty-five healthy subjects underwent a quantitative 3T MRI protocol enabling acquisition of 64 slices with 1 mm in-plane resolution and 2 mm slice thickness in 14 min. Influence of T-1 effects on the estimated water content map is evaluated using a dedicated method including T-1 and T-2* information and region of interest-based water content values are compared with the literature. ResultsOur analysis indicates that the PD bias correction based on T-1 is largely insensitive to T-1 effects. Besides, water content results are in good agreement with literature values obtained at 1.5T. ConclusionThis study demonstrates the applicability of a PD bias correction based on T-1 to yield tissue water content at 3T. Magn Reson Med 72:1735-1745, 2014.
Original languageEnglish
Pages (from-to)1735-1745
JournalMagnetic Resonance in Medicine
Issue number6
Publication statusPublished - Dec 2014


  • quantitative imaging
  • water content
  • cerebral oedema
  • proton density
  • parametric mapping

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