An uncommon side effect of thiamazole treatment in Graves' disease

D. van Moorsel*, R. F. Tummers-de Lind van Wijngaarden

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Thionamides (such as thiamazole/methimazole) are a common first line treatment for Graves' disease. Common side effects include rash, urticaria, and arthralgia. However, thionamide treatment has also been associated with a variety of auto-immune syndromes. Here, we describe a patient presenting with mild arthritis after starting thiamazole. Although severe presentation warrants acute withdrawal of the causative agent, our case suggests that milder forms can be successfully treated with anti-inflammatory drugs alone. Recognition of the syndrome is key to warrant timely and effective treatment.

Original languageEnglish
Pages (from-to)389-391
Number of pages3
JournalNetherlands Journal of Medicine
Issue number6
Publication statusPublished - Dec 2020


  • Arthritis
  • auto-immune
  • Graves' disease
  • methimazole
  • thiamazole
  • thionamides

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