An Official American Thoracic Society/European Respiratory Society Statement: Research Questions in Chronic Obstructive Pulmonary Disease

B.R. Celli, M. Decramer, J.A. Wedzicha, K.C. Wilson*, A. Agustí, G.J. Criner, W. MacNee, B.J. Make, S.I. Rennard, R.A. Stockley, C. Vogelmeier, A. Anzueto, D.H. Au, P.J. Barnes, P.R. Burgel, P.M. Calverley, C. Casanova, E.M. Clini, C.B. Cooper, H.O. CoxsonD.J. Dusser, L.M. Fabbri, B. Fahy, G.T. Ferguson, A. Fisher, M.J. Fletcher, M. Hayot, J.R. Hurst, P.W. Jones, D.A. Mahler, F. Maltais, D.M. Mannino, F.J. Martinez, M. Miravitlles, P.M. Meek, A. Papi, K.F. Rabe, N. Roche, F.C. Sciurba, S. Sethi, N. Siafakas, D.D. Sin, J.B. Soriano, J.K. Stoller, D.P. Tashkin, T. Troosters, G.M. Verleden, J. Verschakelen, J. Vestbo, J.W. Walsh, G.R. Washko, R.A. Wise, E.F.M. Wouters, R.L. ZuWallack, the ATS/ERS Task Force for COPD Research

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality, and resource use worldwide. The goal of this Official American Thoracic Society (ATS)/European Respiratory Society (ERS) Research Statement is to describe evidence related to diagnosis, assessment, and management; identify gaps in knowledge; and make recommendations for future research. It is not intended to provide clinical practice recommendations on COPD diagnosis and management. METHODS: Clinicians, researchers, and patient advocates with expertise in COPD were invited to participate. A literature search of Medline was performed, and studies deemed relevant were selected. The search was not a systematic review of the evidence. Existing evidence was appraised and summarized, and then salient knowledge gaps were identified. RESULTS: Recommendations for research that addresses important gaps in the evidence in all areas of COPD were formulated via discussion and consensus. CONCLUSIONS: Great strides have been made in the diagnosis, assessment, and management of COPD as well as understanding its pathogenesis. Despite this, many important questions remain unanswered. This ATS/ERS Research Statement highlights the types of research that leading clinicians, researchers, and patient advocates believe will have the greatest impact on patient-centered outcomes.
Original languageEnglish
Pages (from-to)e4-e27
JournalAmerican Journal of Respiratory and Critical Care Medicine
Issue number7
Publication statusPublished - 1 Jan 2015

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