TY - JOUR
T1 - An inverse association between the Mediterranean diet and bladder cancer risk
T2 - a pooled analysis of 13 cohort studies
AU - Witlox, Willem J. A.
AU - van Osch, Frits H. M.
AU - Brinkman, Maree
AU - Jochems, Sylvia
AU - Goossens, Maria E.
AU - Weiderpass, Elisabete
AU - White, Emily
AU - van den Brandt, Piet A.
AU - Giles, Graham G.
AU - Milne, Roger L.
AU - Huybrechts, Inge
AU - Adami, Hans-Olov
AU - Bueno-de-Mesquita, Bas
AU - Wesselius, Anke
AU - Zeegers, Maurice P.
N1 - Publisher Copyright:
© 2019, The Author(s).
PY - 2020/2
Y1 - 2020/2
N2 - Purpose The role of diet in bladder carcinogenesis has yet to be established. To date most studies have investigated dietary components individually, rather than as dietary patterns, which may provide stronger evidence for any influence of diet on bladder carcinogenesis. The Mediterranean diet has been associated with many health benefits, but few studies have investigated its association with bladder cancer risk. Methods We investigated the potential association between the Mediterranean diet score (MDS) and risk of developing bladder cancer by pooling 13 prospective cohort studies included in the BLadder cancer Epidemiology and Nutritional Determinants (BLEND) study and applying a Cox regression analysis. Results Dietary data from 646,222 study participants, including 3639 incident bladder cancer cases, were analysed. We observed an inverse association between Mediterranean diet and bladder cancer risk (HRhigh 0.85 [95% CI 0.77, 0.93]). When stratifying the results on non-muscle-invasive or muscle-invasive disease or sex the association remained similar and the HR estimate was consistently below 1.00 both for medium and high adherence to the Mediterranean diet. A consistent association was observed when disregarding fat or alcohol intake. Conclusion We found evidence that adherence to the Mediterranean diet was associated with reduced risk of developing bladder cancer, suggesting a positive effect of the diet as a whole and not just one component.
AB - Purpose The role of diet in bladder carcinogenesis has yet to be established. To date most studies have investigated dietary components individually, rather than as dietary patterns, which may provide stronger evidence for any influence of diet on bladder carcinogenesis. The Mediterranean diet has been associated with many health benefits, but few studies have investigated its association with bladder cancer risk. Methods We investigated the potential association between the Mediterranean diet score (MDS) and risk of developing bladder cancer by pooling 13 prospective cohort studies included in the BLadder cancer Epidemiology and Nutritional Determinants (BLEND) study and applying a Cox regression analysis. Results Dietary data from 646,222 study participants, including 3639 incident bladder cancer cases, were analysed. We observed an inverse association between Mediterranean diet and bladder cancer risk (HRhigh 0.85 [95% CI 0.77, 0.93]). When stratifying the results on non-muscle-invasive or muscle-invasive disease or sex the association remained similar and the HR estimate was consistently below 1.00 both for medium and high adherence to the Mediterranean diet. A consistent association was observed when disregarding fat or alcohol intake. Conclusion We found evidence that adherence to the Mediterranean diet was associated with reduced risk of developing bladder cancer, suggesting a positive effect of the diet as a whole and not just one component.
KW - Mediterranean diet
KW - Bladder cancer
KW - Bladder cancer risk
KW - Epidemiology
KW - UROTHELIAL CELL-CARCINOMA
KW - ANTIOXIDANT CAPACITY
KW - ALCOHOL-CONSUMPTION
KW - MEAT INTAKE
KW - OLIVE OIL
KW - DESIGN
KW - WOMEN
KW - ADHERENCE
KW - EPIDEMIOLOGY
KW - MORTALITY
U2 - 10.1007/s00394-019-01907-8
DO - 10.1007/s00394-019-01907-8
M3 - Article
C2 - 30737562
SN - 1436-6207
VL - 59
SP - 287
EP - 296
JO - European Journal of Nutrition
JF - European Journal of Nutrition
IS - 1
ER -