An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology

Andre P. Lourenco, Adelino F. Leite-Moreira*, Jean-Luc Balligand, Johann Bauersachs, Dana Dawson, Rudolf A. de Boer, Leon J. de Windt, Ines Falcao-Pires, Ricardo Fontes-Carvalho, Stefan Franz, Mauro Giacca, Denise Hilfiker-Kleiner, Emilio Hirsch, Christoph Maack, Manuel Mayr, Burkert Pieske, Thomas Thum, Carlo G. Tocchetti, Dirk L. Brutsaert, Stephane Heymans

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

As heart failure with preserved ejection fraction (HFpEF) rises to epidemic proportions, major steps in patient management and therapeutic development are badly needed. With the current position paper we seek to update our view on HFpEF as a highly complex systemic syndrome, from risk factors and mechanisms to long-term clinical manifestations. We will revise recent advances in animal model development, experimental set-ups and basic and translational science approaches to HFpEF research, highlighting their drawbacks and advantages. Directions are provided for proper model selection as well as for integrative functional evaluation from the in vivo setting to in vitro cell function testing. Additionally, we address new research challenges that require integration of higher-order inter-organ and inter-cell communication to achieve a full systems biology perspective of HFpEF.
Original languageEnglish
Pages (from-to)216-227
Number of pages12
JournalEuropean journal of heart failure
Volume20
Issue number2
DOIs
Publication statusPublished - 1 Feb 2018

Keywords

  • Heart failure with preserved ejection fraction
  • Animal models
  • Experimental evaluation
  • Molecular biology
  • Myocardial function
  • VENTRICULAR DIASTOLIC DYSFUNCTION
  • NONCARDIAC COMORBIDITIES
  • EXERCISE INTOLERANCE
  • PULMONARY-HYPERTENSION
  • CARDIAC STRUCTURE
  • CLINICAL-TRIALS
  • OLDER-ADULTS
  • PRESSURE
  • STRESS
  • TITIN

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