@article{c4de6709b6bd46fa9ce9fd2458e06248,
title = "An injectable, self-healing, 3D printable, double network co-enzymatically crosslinked hydrogel using marine poly- and oligo-saccharides for wound healing application",
abstract = "In this study, we designed dual network hydrogels with antioxidant and antibacterial activities using marine poly-and oligosaccharides with skin wound healing potential. The synergy between dual enzymatic co-crosslinking based on glucose oxidize (GOx)/horseradish peroxidase (HRP) and electrostatic interaction be-tween positively charged chitooligosaccharides (COS) and phenolated chitosan with negatively charged phenolated alginate formed a hydrogel. The Gel-COS hydrogels exhibited toughness, self-healing, moldability, injectability, and 3D printability. Investigation of the physicochemical properties of the hydrogels exhibited a swelling ratio (< 50%) and in vitro biodegradation after 9 days. Furthermore, the hydrogels exhibited antioxidant properties and antibacterial activity against E. coli and S. aureus. The hydrogels were not cytotoxic and enhanced the migration of 3D cell encapsulated 3T3-L1 fibroblasts, blood vessel formation, as well as in vivo wound healing in a rat model. The Gel-COS hydrogel can be considered a promising skin wound dressing material.",
keywords = "Marine polysaccharides, Injectable hydrogels, Glucose oxidize, Enzyme -mediated crosslinking, Wound healing, CHITOSAN OLIGOSACCHARIDE, GELATIN HYDROGELS, ALGINATE, CHITOOLIGOSACCHARIDES, FABRICATION, BEHAVIORS, CHITIN",
author = "H. Jafari and H. Alimoradi and C. Delporte and K.V. Bernaerts and R. Heidari and D. Podstawczyk and S.V. Niknezhad and A. Shavandi",
note = "Funding Information: H.J and A.S. acknowledge funding from Innoviris Brussels, Belgium ( https://innoviris.brussels ) under the project 2019 – BRIDGE – 4: RE4BRU. H.J also acknowledge the FNRS Gustave Bo{\"e}l-Sofina Fellowship. The content is solely the authors' responsibility and does not necessarily represent the official views of the above-mentioned funding agency. The authors acknowledge the facilities and technical assistance from CARAMAT staff at the ULB; besides, the authors acknowledge Dr. V{\'e}ronique Fontaine for the facilities and scientific assistance for performing the antibacterial test. D.P. acknowledges the support from the Polish National Science Centre (2016/23/D/ST8/01267) and from the Academia Iuvenum, Wroc{\l}aw University of Science and Technology. The authors acknowledge Dr. Jonathan Goole for the facilities and scientific assistance for performing the zeta potential test. Funding Information: H.J and A.S. acknowledge funding from Innoviris Brussels, Belgium (https://innoviris.brussels) under the project 2019 – BRIDGE – 4: RE4BRU. H.J also acknowledge the FNRS Gustave Bo{\"e}l-Sofina Fellowship. The content is solely the authors' responsibility and does not necessarily represent the official views of the above-mentioned funding agency. The authors acknowledge the facilities and technical assistance from CARAMAT staff at the ULB; besides, the authors acknowledge Dr. V{\'e}ronique Fontaine for the facilities and scientific assistance for performing the antibacterial test. D.P. acknowledges the support from the Polish National Science Centre (2016/23/D/ST8/01267) and from the Academia Iuvenum, Wroc{\l}aw University of Science and Technology. The authors acknowledge Dr. Jonathan Goole for the facilities and scientific assistance for performing the zeta potential test. Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",
year = "2022",
month = dec,
day = "1",
doi = "10.1016/j.apmt.2022.101581",
language = "English",
volume = "29",
journal = "Applied Materials Today",
issn = "2352-9407",
publisher = "Elsevier BV",
}