An inhibitor of clot formation in cord plasma

B.R.J. Kirchhof; A.D. Muller; H.C. Hemker

doi:10.1016/0049-3848(79)90146-4

An inhibitor of clot formation in cord plasma

B.R.J. Kirchhof^*
, A.D. Muller
, H.C. Hemker

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

An inhibitor of the coagulation in [human] cord plasma could be extracted by phosphotungstic acid or acetone. Action of this inhibitor was tested by means of synthetic chromogenic substrates, thrombin times, 2-stage thrombin generation tests and thrombelastography. This inhibitor seemed to act mainly on fibrin behavior. The inhibitor may also have had a small effect on thrombin or thrombin generation. Some differences in the coagulation of adult and newborn plasma may be explained by this newborn inhibitor.

Original language	English
Pages (from-to)	389-403
Number of pages	15
Journal	Thrombosis Research
Volume	15
Issue number	3/4
DOIs	https://doi.org/10.1016/0049-3848(79)90146-4
Publication status	Published - 1979

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title = "An inhibitor of clot formation in cord plasma",

abstract = "An inhibitor of the coagulation in [human] cord plasma could be extracted by phosphotungstic acid or acetone. Action of this inhibitor was tested by means of synthetic chromogenic substrates, thrombin times, 2-stage thrombin generation tests and thrombelastography. This inhibitor seemed to act mainly on fibrin behavior. The inhibitor may also have had a small effect on thrombin or thrombin generation. Some differences in the coagulation of adult and newborn plasma may be explained by this newborn inhibitor.",

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AU - Kirchhof, B.R.J.

AU - Muller, A.D.

AU - Hemker, H.C.

PY - 1979

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N2 - An inhibitor of the coagulation in [human] cord plasma could be extracted by phosphotungstic acid or acetone. Action of this inhibitor was tested by means of synthetic chromogenic substrates, thrombin times, 2-stage thrombin generation tests and thrombelastography. This inhibitor seemed to act mainly on fibrin behavior. The inhibitor may also have had a small effect on thrombin or thrombin generation. Some differences in the coagulation of adult and newborn plasma may be explained by this newborn inhibitor.

AB - An inhibitor of the coagulation in [human] cord plasma could be extracted by phosphotungstic acid or acetone. Action of this inhibitor was tested by means of synthetic chromogenic substrates, thrombin times, 2-stage thrombin generation tests and thrombelastography. This inhibitor seemed to act mainly on fibrin behavior. The inhibitor may also have had a small effect on thrombin or thrombin generation. Some differences in the coagulation of adult and newborn plasma may be explained by this newborn inhibitor.

U2 - 10.1016/0049-3848(79)90146-4

DO - 10.1016/0049-3848(79)90146-4

M3 - Article

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VL - 15

SP - 389

EP - 403

JO - Thrombosis Research

JF - Thrombosis Research

IS - 3/4

ER -

An inhibitor of clot formation in cord plasma

Abstract

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