An in vitro and in vivo study of peptide-functionalized nanoparticles for brain targeting: The importance of selective blood-brain barrier uptake

Gerard H. Bode, Gregory Coue, Christian Freese, Karin E. Pickl, Maria Sanchez-Purra, Berta Albaiges, Salvador Borros, Ewoud C. van Winden, Leto-Aikaterini Tziveleka, Zili Sideratou, Johan F. J. Engbersen, Smriti Singh, Krystyna Albrecht, Juergen Groll, Martin Moeller, Andy J. G. Poetgens, Christoph Schmitzk, Eleonore Froehlich, Christian Grandfils, Frank M. SinnerC. James Kirkpatrick, Harry W. M. Steinbusch, Hans-Georg Frank, Ronald E. Unger, Pilar Martinez-Martinez*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1289-1300
Number of pages12
JournalNanomedicine-Nanotechnology Biology and Medicine
Volume13
Issue number3
DOIs
Publication statusPublished - Apr 2017

Keywords

  • Nanoparticles
  • Peptides
  • Brain
  • Targeting
  • 80-COATED POLYBUTYLCYANOACRYLATE NANOPARTICLES
  • DRUG-DELIVERY
  • SENSITIVE HYDROGELS
  • MEDIATED TRANSPORT
  • DENDRITIC POLYMERS
  • NANOGELS
  • CELLS
  • DENDRIMERS
  • LIPOSOMES
  • METHOTREXATE

Cite this

Bode, G. H., Coue, G., Freese, C., Pickl, K. E., Sanchez-Purra, M., Albaiges, B., Borros, S., van Winden, E. C., Tziveleka, L-A., Sideratou, Z., Engbersen, J. F. J., Singh, S., Albrecht, K., Groll, J., Moeller, M., Poetgens, A. J. G., Schmitzk, C., Froehlich, E., Grandfils, C., ... Martinez-Martinez, P. (2017). An in vitro and in vivo study of peptide-functionalized nanoparticles for brain targeting: The importance of selective blood-brain barrier uptake. Nanomedicine-Nanotechnology Biology and Medicine, 13(3), 1289-1300. https://doi.org/10.1016/j.nano.2016.11.009