An Exploratory Study to Detect Meniere's Disease in Conventional MRI Scans Using Radiomics

E. L. van den Burg; M. van Hoof; Linda Postma - Jacobi; A. M. L. Janssen; R. J. Stokroos; H. Kingma; R. van de Berg

doi:10.3389/fneur.2016.00190

An Exploratory Study to Detect Meniere's Disease in Conventional MRI Scans Using Radiomics

E. L. van den Burg, M. van Hoof, Linda Postma - Jacobi, A. M. L. Janssen, R. J. Stokroos, H. Kingma, R. van de Berg^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Web of Science)

Abstract

Objective: The purpose of this exploratory study was to investigate whether a quantitative image analysis of the labyrinth in conventional magnetic resonance imaging (MRI) scans using a radiomics approach showed differences between patients with Meniere's disease (MD) and the control group. Materials and methods: In this retrospective study, MRI scans of the affected labyrinths of 24 patients with MD were compared to the MRI scans of labyrinths of 29 patients with an idiopathic asymmetrical sensorineural hearing loss. The 1.5- and 3-T MRI scans had been previously made in a clinical setting between 2008 and 2015. 3D Slicer 4.4 was used to extract several substructures of the labyrinth. A quantitative analysis of the normalized radiomic image features was performed in Mathematica 10. The image features of the two groups were statistically compared. Results: For numerous image features, there was a statistically significant difference (p-value

Original language	English
Article number	190
Journal	Frontiers in Neurology
Volume	7
DOIs	https://doi.org/10.3389/fneur.2016.00190
Publication status	Published - 7 Nov 2016

Keywords

Meniere's disease
MRI
imaging
radiomics
quantitative image analysis
labyrinth
3D models
vertigo

Access to Document

10.3389/fneur.2016.00190

Cite this

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title = "An Exploratory Study to Detect Meniere's Disease in Conventional MRI Scans Using Radiomics",

abstract = "Objective: The purpose of this exploratory study was to investigate whether a quantitative image analysis of the labyrinth in conventional magnetic resonance imaging (MRI) scans using a radiomics approach showed differences between patients with Meniere's disease (MD) and the control group. Materials and methods: In this retrospective study, MRI scans of the affected labyrinths of 24 patients with MD were compared to the MRI scans of labyrinths of 29 patients with an idiopathic asymmetrical sensorineural hearing loss. The 1.5- and 3-T MRI scans had been previously made in a clinical setting between 2008 and 2015. 3D Slicer 4.4 was used to extract several substructures of the labyrinth. A quantitative analysis of the normalized radiomic image features was performed in Mathematica 10. The image features of the two groups were statistically compared. Results: For numerous image features, there was a statistically significant difference (p-value ",

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author = "{van den Burg}, {E. L.} and {van Hoof}, M. and {Postma - Jacobi}, Linda and Janssen, {A. M. L.} and Stokroos, {R. J.} and H. Kingma and {van de Berg}, R.",

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AU - van den Burg, E. L.

AU - van Hoof, M.

AU - Postma - Jacobi, Linda

AU - Janssen, A. M. L.

AU - Stokroos, R. J.

AU - Kingma, H.

AU - van de Berg, R.

PY - 2016/11/7

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AB - Objective: The purpose of this exploratory study was to investigate whether a quantitative image analysis of the labyrinth in conventional magnetic resonance imaging (MRI) scans using a radiomics approach showed differences between patients with Meniere's disease (MD) and the control group. Materials and methods: In this retrospective study, MRI scans of the affected labyrinths of 24 patients with MD were compared to the MRI scans of labyrinths of 29 patients with an idiopathic asymmetrical sensorineural hearing loss. The 1.5- and 3-T MRI scans had been previously made in a clinical setting between 2008 and 2015. 3D Slicer 4.4 was used to extract several substructures of the labyrinth. A quantitative analysis of the normalized radiomic image features was performed in Mathematica 10. The image features of the two groups were statistically compared. Results: For numerous image features, there was a statistically significant difference (p-value

KW - Meniere's disease

KW - MRI

KW - imaging

KW - radiomics

KW - quantitative image analysis

KW - labyrinth

KW - 3D models

KW - vertigo

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