@article{94a73a74021c4342b97f8379b8d28e29,
title = "An Efficient Thermal Elimination Pathway toward Phosphodiester Hydrogels via a Precursor Approach",
abstract = "Phosphodiester hydrogels offer a wide range of fascinating properties. Not only do they exhibit excellent hemocompatibility and cellular compatibility, they also show a remarkable resistance to protein adsorption, thereby limiting the foreign body response. In this work, phosphodiester-crosslinked hydrogels are produced by a simple free-radical polymerization of a phosphotriester crosslinker. In a second step, this material is transformed to the phosphodiester, by heating it up to 60 degrees C in phosphate-buffered saline. Compared to earlier methods, there is no need for acids, bases, or oxidizing agents to achieve this final conversion to the phosphodiester. This method thus reduces the risk to damage or degrade any sensitive biomolecules that might be of interest to tissue engineers, such as various growth factors or other proteins. The phosphotriester crosslinker is readily synthesized out of common laboratory chemicals in multigram quantities with good yield and easy workup and purification.",
keywords = "biomaterials, hydrogels, phosphodiesters, RING-OPENING POLYMERIZATION, SOLID-STATE NMR, PHOSPHORAMIDITE, POLYMERS, BLENDS",
author = "Rafael Dera and Hanne Dilien and Peter Adriaensens and Wanda Guedens and Cleij, {Thomas J.}",
note = "Funding Information: R.D. and H.D. contributed equally to this work and should be considered joint first author. This study is part of the Euregional Meuse‐Rhine Interreg IVa project “BioMIMedics” ( www.biomimedics.org ). The Universities of Maastricht (The Netherlands), Li{\`e}ge (Belgium), Hasselt (Belgium), and Aachen (RWTH and Fachhochschule, Germany), as well as several regional biotechnological enterprises cooperate in “BioMIMedics” to develop novel biocompatible and biobased materials. The authors further acknowledge the financial support from the Interuniversity Attraction Poles Programme (P7/05) initiated by the Belgian Science Policy Office (BELSPO). R.D. wishes to acknowledge Hasselt University's BOF program. The DMA analysis was performed by Prof. Dietmar Auhl and Nils Leone (AMIBM, Maastricht University). Funding Information: R.D. and H.D. contributed equally to this work and should be considered joint first author. This study is part of the Euregional Meuse-Rhine Interreg IVa project ?BioMIMedics? (www.biomimedics.org). The Universities of Maastricht (The Netherlands), Li?ge (Belgium), Hasselt (Belgium), and Aachen (RWTH and Fachhochschule, Germany), as well as several regional biotechnological enterprises cooperate in ?BioMIMedics? to develop novel biocompatible and biobased materials. The authors further acknowledge the financial support from the Interuniversity Attraction Poles Programme (P7/05) initiated by the Belgian Science Policy Office (BELSPO). R.D. wishes to acknowledge Hasselt University's BOF program. The DMA analysis was performed by Prof. Dietmar Auhl and Nils Leone (AMIBM, Maastricht University). Publisher Copyright: {\textcopyright} 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2020",
month = mar,
doi = "10.1002/macp.201900466",
language = "English",
volume = "221",
journal = "Macromolecular Chemistry and Physics",
issn = "1022-1352",
publisher = "Wiley-VCH Verlag",
number = "5",
}