An EEG Signature of Suicidal Behavior in Female Patients with Major Depressive Disorder?: A Non-Replication

Noralie Krepel; Lars Benschop; Chris Baeken; Alexander T. Sack; Martijn Arns

doi:10.1016/j.biopsycho.2021.108058

An EEG Signature of Suicidal Behavior in Female Patients with Major Depressive Disorder? A Non-Replication

Noralie Krepel
, Lars Benschop
, Chris Baeken
, Alexander T. Sack
, Martijn Arns^*

^*Corresponding author for this work

Neuroplasticity, Synchrony & Cognition

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

INTRODUCTION: A recent study showed hypoactivity in the beta/gamma band in female suicide ideators and suicide attempters diagnosed with depression, relative to a low-risk group. The current study aimed to conceptually replicate these results.

METHODS: In the iSPOT-D sample (n = 402), suicide ideators and low-risk individuals were identified. Confining analyses to females only, differences between low-risk individuals and suicide ideators were tested for using the electroencephalogram (EEG) frequency bands SMR (Sensori-Motor-Rhythm; 12-15 Hz), beta (14.5-30 Hz), beta I (14.5-20 Hz), beta II (20-25 Hz), beta III (25-30 Hz), gamma I (31-49 Hz) using LORETA-software.

RESULTS: None of the tested frequency bands showed to be significantly different between suicide ideators and low-risk individuals.

CONCLUSIONS: The current study could not conceptually replicate the earlier published results. Several reasons could explain this non-replication, among which possible electromyographic (EMG) contamination in the beta/gamma band in the original study.

TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00693849 URL: http://clinicaltrials.gov/ct2/show/NCT00693849.

Original language	English
Article number	108058
Number of pages	4
Journal	Biological Psychology
Volume	161
Early online date	26 Feb 2021
DOIs	https://doi.org/10.1016/j.biopsycho.2021.108058
Publication status	Published - Apr 2021

Keywords

Suicide
Electroencephalogram (EEG)
Replication
PREDICT OPTIMIZED TREATMENT
HIGH-FREQUENCY
ISPOT-D
IDEATION
OSCILLATIONS
ANTAGONISTS
POWER
ADHD

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Cite this

@article{ae161aa4424c45929221ec5d771991bf,

title = "An EEG Signature of Suicidal Behavior in Female Patients with Major Depressive Disorder?: A Non-Replication",

abstract = "INTRODUCTION: A recent study showed hypoactivity in the beta/gamma band in female suicide ideators and suicide attempters diagnosed with depression, relative to a low-risk group. The current study aimed to conceptually replicate these results.METHODS: In the iSPOT-D sample (n = 402), suicide ideators and low-risk individuals were identified. Confining analyses to females only, differences between low-risk individuals and suicide ideators were tested for using the electroencephalogram (EEG) frequency bands SMR (Sensori-Motor-Rhythm; 12-15 Hz), beta (14.5-30 Hz), beta I (14.5-20 Hz), beta II (20-25 Hz), beta III (25-30 Hz), gamma I (31-49 Hz) using LORETA-software.RESULTS: None of the tested frequency bands showed to be significantly different between suicide ideators and low-risk individuals.CONCLUSIONS: The current study could not conceptually replicate the earlier published results. Several reasons could explain this non-replication, among which possible electromyographic (EMG) contamination in the beta/gamma band in the original study.TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00693849 URL: http://clinicaltrials.gov/ct2/show/NCT00693849.",

keywords = "Suicide, Electroencephalogram (EEG), Replication, PREDICT OPTIMIZED TREATMENT, HIGH-FREQUENCY, ISPOT-D, IDEATION, OSCILLATIONS, ANTAGONISTS, POWER, ADHD",

author = "Noralie Krepel and Lars Benschop and Chris Baeken and Sack, \{Alexander T.\} and Martijn Arns",

note = "Copyright {\textcopyright} 2021. Published by Elsevier B.V.",

year = "2021",

month = apr,

doi = "10.1016/j.biopsycho.2021.108058",

language = "English",

volume = "161",

journal = "Biological Psychology",

issn = "0301-0511",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - An EEG Signature of Suicidal Behavior in Female Patients with Major Depressive Disorder?

T2 - A Non-Replication

AU - Krepel, Noralie

AU - Benschop, Lars

AU - Baeken, Chris

AU - Sack, Alexander T.

AU - Arns, Martijn

PY - 2021/4

Y1 - 2021/4

N2 - INTRODUCTION: A recent study showed hypoactivity in the beta/gamma band in female suicide ideators and suicide attempters diagnosed with depression, relative to a low-risk group. The current study aimed to conceptually replicate these results.METHODS: In the iSPOT-D sample (n = 402), suicide ideators and low-risk individuals were identified. Confining analyses to females only, differences between low-risk individuals and suicide ideators were tested for using the electroencephalogram (EEG) frequency bands SMR (Sensori-Motor-Rhythm; 12-15 Hz), beta (14.5-30 Hz), beta I (14.5-20 Hz), beta II (20-25 Hz), beta III (25-30 Hz), gamma I (31-49 Hz) using LORETA-software.RESULTS: None of the tested frequency bands showed to be significantly different between suicide ideators and low-risk individuals.CONCLUSIONS: The current study could not conceptually replicate the earlier published results. Several reasons could explain this non-replication, among which possible electromyographic (EMG) contamination in the beta/gamma band in the original study.TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00693849 URL: http://clinicaltrials.gov/ct2/show/NCT00693849.

AB - INTRODUCTION: A recent study showed hypoactivity in the beta/gamma band in female suicide ideators and suicide attempters diagnosed with depression, relative to a low-risk group. The current study aimed to conceptually replicate these results.METHODS: In the iSPOT-D sample (n = 402), suicide ideators and low-risk individuals were identified. Confining analyses to females only, differences between low-risk individuals and suicide ideators were tested for using the electroencephalogram (EEG) frequency bands SMR (Sensori-Motor-Rhythm; 12-15 Hz), beta (14.5-30 Hz), beta I (14.5-20 Hz), beta II (20-25 Hz), beta III (25-30 Hz), gamma I (31-49 Hz) using LORETA-software.RESULTS: None of the tested frequency bands showed to be significantly different between suicide ideators and low-risk individuals.CONCLUSIONS: The current study could not conceptually replicate the earlier published results. Several reasons could explain this non-replication, among which possible electromyographic (EMG) contamination in the beta/gamma band in the original study.TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00693849 URL: http://clinicaltrials.gov/ct2/show/NCT00693849.

KW - Suicide

KW - Electroencephalogram (EEG)

KW - Replication

KW - PREDICT OPTIMIZED TREATMENT

KW - HIGH-FREQUENCY

KW - ISPOT-D

KW - IDEATION

KW - OSCILLATIONS

KW - ANTAGONISTS

KW - POWER

KW - ADHD

U2 - 10.1016/j.biopsycho.2021.108058

DO - 10.1016/j.biopsycho.2021.108058

M3 - (Systematic) Review article

C2 - 33647333

SN - 0301-0511

VL - 161

JO - Biological Psychology

JF - Biological Psychology

M1 - 108058

ER -

An EEG Signature of Suicidal Behavior in Female Patients with Major Depressive Disorder? A Non-Replication

Abstract

Keywords

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