An association study of sequence variants in the forkhead box P2 (FOXP2) gene and adulthood attention-deficit/hyperactivity disorder in two European samples

Marta Ribases, Cristina Sanchez-Mora, Josep Antoni Ramos-Quiroga, Rosa Bosch, Nuria Gomez, Mariana Nogueira, Montse Corrales, Gloria Palomar, Christian P. Jacob, Silke Gross-Lesch, Susanne Kreiker, Andreas Reif, Klaus Peter Lesch, Bru Cormand, Miquel Casas, Monica Bayes*

*Corresponding author for this work

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Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder manifesting as symptoms of inattention, hyperactivity, and/or impulsivity. Learning disabilities co-occur with ADHD in 20-30% of cases and this high co-occurrence raises the possibility of a common etiological background. Forkhead box P2 (FOXP2) encodes a transcription factor involved in speech and language impairment and in the control of the corticobasal ganglia circuits known to be relevant in ADHD, suggesting a possible role of FOXP2 in ADHD. Our aim was to carry out an association study between FOXP2 and adulthood ADHD.We carried out a case-control association study in 643 adult ADHD patients and 619 controls from Germany and in 361 adult ADHD patients and 442 controls from Spain with 12 tagging single nucleotide polymorphisms covering the FOXP2 gene.The single-marker and multiple-marker analyses showed an association between FOXP2 and combined ADHD in the German cohort [rs12533005: P=0.0033; odds ratio=1.30 (1.09-1.56); rs12533005/rs1229761: P=4.1e-04; odds ratio=1.38 (1.15-1.66)]. These positive results, however, were not confirmed in the Spanish sample.Although these preliminary findings provide a tentative evidence for the contribution of FOXP2 to ADHD and suggest common genetic factors for this psychiatric disorder and learning disabilities, they should be interpreted with caution. Further studies in larger samples are needed to clarify the role of this transcription factor in ADHD.
Original languageEnglish
Pages (from-to)155-160
JournalPsychiatric Genetics
Volume22
Issue number4
DOIs
Publication statusPublished - Aug 2012

Keywords

  • attention-deficit hyperactivity disorder
  • case-control association study
  • forkhead box P2
  • learning disability
  • single nucleotide polymorphism

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