An adapted protocol for magnetic localisation of nonpalpable breast cancer lesions and sentinel lymph nodes using a magnetic seed and superparamagnetic iron oxide tracer

M.A.S. van Weezelenburg*, E.R.M. van Haaren, L. Aldenhoven, C.N.A. Frotscher, R. Korver-Steeman, J. van Bastelaar, L.H. Bouwman, Y.L.J. Vissers, A. Janssen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


BackgroundLocalisation techniques for nonpalpable breast cancer lesions and sentinel lymph node biopsy (SLNB) are associated with several drawbacks. A complete magnetic technique using magnetic seeds and superparamagnetic iron oxide tracer could be an interesting alternative. This study describes a clear protocol and the results of a combined magnetic approach. MethodsFrom August 2021 to February 2022 40 patients undergoing breast conserving surgery with SLNB were eligible for inclusion. Localisation was performed under ultrasound or stereotactic guidance, 1 week before surgery. Subsequently, 1 ml of tracer was injected at least 4 cm away from the tumour. Technetium-99m (Tc-99m) was injected 1 day before surgery as control procedure. Outcomes were SLNB time, a number of nodes detected with magnetic tracer including comparison with Tc-99m, a success rate of malignant lesion detection and pathological margin assessment. ResultsIn total, 40 procedures were performed on 39 patients. A median of one node was retrieved. Sentinel nodes were retrieved using MagTrace (R) with a 92.5% detection rate compared to Tc-99m. Wide local excision under magnetic guidance was successful in 35 cases. ConclusionsThis paper describes a combined magnetic approach for breast-conserving surgery and SLNB. An adapted protocol is described and could be used for implementation.
Original languageEnglish
Number of pages6
JournalJournal of Surgical Oncology
Publication statusE-pub ahead of print - 1 Jan 2023


  • magnetic tracer
  • MagSeed
  • MagTrace
  • sentinel lymph node biopsy

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