An acute intake of theobromine does not change postprandial lipid metabolism, whereas a high-fat meal lowers chylomicron particle number

Lotte Smolders, Ronald P. Mensink, Jogchum Plat*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Web of Science)

Abstract

Postprandial responses predict cardiovascular disease risk. However, only a few studies have compared acute postprandial effects of a low-fat, high-carbohydrate (LF) meal with a high-fat, low-carbohydrate (HF) meal. Furthermore, theobromine has favorably affected fasting lipids, but postprandial effects are unknown. Because both fat and theobromine have been reported to increase fasting apolipoprotein A-I (apoA-I) concentrations, the main hypothesis of this randomized, double-blind crossover study was that acute consumption of an HF meal and a theobromine meal increased postprandial apoA-I concentrations, when compared with an LF meal. Theobromine was added to the LF meal. Nine healthy men completed the study. After meal intake, blood was sampled frequently for 4 hours. Postprandial apoA-I concentrations were comparable after intake of the 3 meals. Apolipoprotein B48 curves, however, were significantly lower and those of triacylglycerol were significantly higher after HF as compared with LF consumption. Postprandial free fatty acid concentrations decreased less, and glucose and insulin concentrations increased less after HF meal consumption. Except for an increase in the incremental area under the curve for insulin, theobromine did not modify responses of the LF meal. These data show that acute HF and theobromine consumption does not change postprandial apoA-I concentrations. Furthermore, acute HF consumption had divergent effects on postprandial apolipoprotein B48 and triacylglycerol responses, suggesting the formation of less, but larger chylomicrons after HF intake. Finally, except for an increase in the incremental area under the curve for insulin, acute theobromine consumption did not modify the postprandial responses of the LF meal. (C) 2017 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)85-94
Number of pages10
JournalNutrition Research
Volume40
DOIs
Publication statusPublished - Apr 2017

Keywords

  • Human
  • Postprandial
  • Metabolism
  • Dietary fat
  • Theobromine
  • LIPOPROTEIN METABOLISM
  • CARDIOVASCULAR EVENTS
  • APOLIPOPROTEIN B-48
  • DIABETIC-PATIENTS
  • HDL-CHOLESTEROL
  • SERUM-LIPIDS
  • GLUCOSE
  • METAANALYSIS
  • RESPONSES
  • INSULIN

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