Amyloid-beta Interacts with Blood-Brain Barrier Function in Dementia: A Systematic Review

Saartje Burgmans*, Harm J. van de Haar, Frans R. J. Verhey, Walter H. Backes

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Web of Science)

Abstract

To date, the exact pathogenesis of dementia is still unknown. The most frequently hypothesized initiating factor is an accumulation of the protein amyloid-beta in the brain, which has been associated with dementia of the Alzheimer type. Another potentially important initiating factor is a disrupted blood-brain barrier. This can initiate cerebral microangiopathy, which has frequently been associated with vascular dementia. Although amyloid-beta and blood-brain barrier dysfunction have both been associated with one particular type of dementia (Alzheimer's disease and vascular dementia, respectively), they co-exist in most demented patients. In fact, increasing evidence indicates that amyloid-beta and blood-brain barrier disruption may interact and facilitate each other in their effect on neurodegeneration. The present systematic analysis describes the available evidence for a significant interplay between amyloid-beta and blood-brain barrier function in dementia.
Original languageEnglish
Pages (from-to)859-873
JournalJournal of Alzheimer's Disease
Volume35
Issue number4
DOIs
Publication statusPublished - 2013

Keywords

  • Alzheimer's disease
  • amyloid-beta
  • blood-brain barrier
  • dementia
  • vascular dementia

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