Amygdala atrophy affects emotion-related activity in face-responsive regions in frontotemporal degeneration

François-Laurent De Winter, Jan Van den Stock, Beatrice de Gelder, Ronald Peeters, Jan Jastorff, Stefan Sunaert, Wim Vanduffel, Rik Vandenberghe, Mathieu Vandenbulcke

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

In the healthy brain, modulatory influences from the amygdala commonly explain enhanced activation in face-responsive areas by emotional facial expressions relative to neutral expressions. In the behavioral variant frontotemporal dementia (bvFTD) facial emotion recognition is impaired and has been associated with atrophy of the amygdala. By combining structural and functional MRI in 19 patients with bvFTD and 20 controls we investigated the neural effects of emotion in face-responsive cortex and its relationship with amygdalar gray matter (GM) volume in neurodegeneration. Voxel-based morphometry revealed decreased GM volume in anterior medio-temporal regions including amygdala in patients compared to controls. During fMRI, we presented dynamic facial expressions (fear and chewing) and their spatiotemporally scrambled versions. We found enhanced activation for fearful compared to neutral faces in ventral temporal cortex and superior temporal sulcus in controls, but not in patients. In the bvFTD group left amygdalar GM volume correlated positively with emotion-related activity in left fusiform face area (FFA). This correlation was amygdala-specific and driven by GM in superficial and basolateral (BLA) subnuclei, consistent with reported amygdalar-cortical networks. The data suggests that anterior medio-temporal atrophy in bvFTD affects emotion processing in distant posterior areas.

Original languageEnglish
Pages (from-to)179-191
Number of pages13
JournalCortex
Volume82
DOIs
Publication statusPublished - Sep 2016

Keywords

  • Amygdala
  • Behavioral variant frontotemporal dementia
  • Dynamic face processing
  • Emotion processing
  • fMRI
  • VISUAL CORTICAL ACTIVATION
  • BEHAVIORAL-VARIANT
  • FACIAL EXPRESSIONS
  • LOBAR DEGENERATION
  • ALZHEIMERS-DISEASE
  • TEMPORAL CORTEX
  • DEMENTIA
  • BRAIN
  • CONNECTIVITY
  • RECOGNITION

Cite this

De Winter, F-L., Van den Stock, J., de Gelder, B., Peeters, R., Jastorff, J., Sunaert, S., ... Vandenbulcke, M. (2016). Amygdala atrophy affects emotion-related activity in face-responsive regions in frontotemporal degeneration. Cortex, 82, 179-191. https://doi.org/10.1016/j.cortex.2016.06.001
De Winter, François-Laurent ; Van den Stock, Jan ; de Gelder, Beatrice ; Peeters, Ronald ; Jastorff, Jan ; Sunaert, Stefan ; Vanduffel, Wim ; Vandenberghe, Rik ; Vandenbulcke, Mathieu. / Amygdala atrophy affects emotion-related activity in face-responsive regions in frontotemporal degeneration. In: Cortex. 2016 ; Vol. 82. pp. 179-191.
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abstract = "In the healthy brain, modulatory influences from the amygdala commonly explain enhanced activation in face-responsive areas by emotional facial expressions relative to neutral expressions. In the behavioral variant frontotemporal dementia (bvFTD) facial emotion recognition is impaired and has been associated with atrophy of the amygdala. By combining structural and functional MRI in 19 patients with bvFTD and 20 controls we investigated the neural effects of emotion in face-responsive cortex and its relationship with amygdalar gray matter (GM) volume in neurodegeneration. Voxel-based morphometry revealed decreased GM volume in anterior medio-temporal regions including amygdala in patients compared to controls. During fMRI, we presented dynamic facial expressions (fear and chewing) and their spatiotemporally scrambled versions. We found enhanced activation for fearful compared to neutral faces in ventral temporal cortex and superior temporal sulcus in controls, but not in patients. In the bvFTD group left amygdalar GM volume correlated positively with emotion-related activity in left fusiform face area (FFA). This correlation was amygdala-specific and driven by GM in superficial and basolateral (BLA) subnuclei, consistent with reported amygdalar-cortical networks. The data suggests that anterior medio-temporal atrophy in bvFTD affects emotion processing in distant posterior areas.",
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De Winter, F-L, Van den Stock, J, de Gelder, B, Peeters, R, Jastorff, J, Sunaert, S, Vanduffel, W, Vandenberghe, R & Vandenbulcke, M 2016, 'Amygdala atrophy affects emotion-related activity in face-responsive regions in frontotemporal degeneration', Cortex, vol. 82, pp. 179-191. https://doi.org/10.1016/j.cortex.2016.06.001

Amygdala atrophy affects emotion-related activity in face-responsive regions in frontotemporal degeneration. / De Winter, François-Laurent; Van den Stock, Jan; de Gelder, Beatrice; Peeters, Ronald; Jastorff, Jan; Sunaert, Stefan; Vanduffel, Wim; Vandenberghe, Rik; Vandenbulcke, Mathieu.

In: Cortex, Vol. 82, 09.2016, p. 179-191.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Amygdala atrophy affects emotion-related activity in face-responsive regions in frontotemporal degeneration

AU - De Winter, François-Laurent

AU - Van den Stock, Jan

AU - de Gelder, Beatrice

AU - Peeters, Ronald

AU - Jastorff, Jan

AU - Sunaert, Stefan

AU - Vanduffel, Wim

AU - Vandenberghe, Rik

AU - Vandenbulcke, Mathieu

N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.

PY - 2016/9

Y1 - 2016/9

N2 - In the healthy brain, modulatory influences from the amygdala commonly explain enhanced activation in face-responsive areas by emotional facial expressions relative to neutral expressions. In the behavioral variant frontotemporal dementia (bvFTD) facial emotion recognition is impaired and has been associated with atrophy of the amygdala. By combining structural and functional MRI in 19 patients with bvFTD and 20 controls we investigated the neural effects of emotion in face-responsive cortex and its relationship with amygdalar gray matter (GM) volume in neurodegeneration. Voxel-based morphometry revealed decreased GM volume in anterior medio-temporal regions including amygdala in patients compared to controls. During fMRI, we presented dynamic facial expressions (fear and chewing) and their spatiotemporally scrambled versions. We found enhanced activation for fearful compared to neutral faces in ventral temporal cortex and superior temporal sulcus in controls, but not in patients. In the bvFTD group left amygdalar GM volume correlated positively with emotion-related activity in left fusiform face area (FFA). This correlation was amygdala-specific and driven by GM in superficial and basolateral (BLA) subnuclei, consistent with reported amygdalar-cortical networks. The data suggests that anterior medio-temporal atrophy in bvFTD affects emotion processing in distant posterior areas.

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KW - VISUAL CORTICAL ACTIVATION

KW - BEHAVIORAL-VARIANT

KW - FACIAL EXPRESSIONS

KW - LOBAR DEGENERATION

KW - ALZHEIMERS-DISEASE

KW - TEMPORAL CORTEX

KW - DEMENTIA

KW - BRAIN

KW - CONNECTIVITY

KW - RECOGNITION

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DO - 10.1016/j.cortex.2016.06.001

M3 - Article

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JO - Cortex

JF - Cortex

SN - 0010-9452

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