AMPK-glycogen interplay: an opportunity for drug design

M. Miglianico

Research output: ThesisDoctoral ThesisInternal

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Abstract

Type 2 diabetes is the form of diabetes associated with age and/or poor lifestyle. On a cellular and whole body level, the balance between energy intake (food) and expenditure (physical activity) is of primordial importance to maintain health. One of the major cellular actors that control this balance is AMPK, the protein that was studied throughout this thesis. In this work, the inter-regulation between AMPK and the cellular storage of glucose, called glycogen, was particularly studied. Importantly, new small molecules that target AMPK were identified: these molecules may in the future be developed into a new drug to target diabetes.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Glatz, Jan, Supervisor
  • Neumann, D., Advisor, External person
  • Nicolaes, Gerry, Advisor
Award date23 Oct 2015
Place of PublicationMaastricht
Publisher
Print ISBNs9789090292823
Publication statusPublished - 2015

Keywords

  • drug design
  • virtual ligand screening
  • metabolic diseases
  • AMP-activated protein kinase
  • glycogen
  • molecular biology

Cite this

Miglianico, M. (2015). AMPK-glycogen interplay: an opportunity for drug design. Maastricht University.