Amphiphilic Crosslinked Four-Armed Poly(lactic-co-glycolide) Electrospun Membranes for Enhancing Cell Adhesion

Jidong Dai, Zhigang Zhang, Katrien V Bernaerts, Qianli Zhang, Tianzhu Zhang

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Common poly(lactide-co-glycolide) (i-PLGA) has emerged as a biodegradable and biocompatible material in tissue engineering. However, the poor hydrophilicity and elasticity of i-PLGA lead to its limited application in tissue engineering. To this end, an amphiphilic crosslinked four-armed poly(lactic-co-glycolide) was prepared. First, four-armed PLGA (4A-PLGA) was synthesized by polymerizing l-lactide (LA) and glycolide (GA) with pentaerythritol as the initiator. Then, the hydrophilic polymer poly(glutamate propylene ester) (PGPE) was prepared through the esterification of glutamic acid and 1,2-propanediol. The hydrophilic 4A-PLGA-PGPE was finally synthesized through the condensation reaction of 4A-PLGA and PGPE with the aid of triphosgene. 4A-PLGA-PGPE was then used to prepare amphiphilic membranes by electrospinning. It was demonstrated that the mechanical properties and biocompatibility of 4A-PLGA were improved after the introduction of PGPE. Furthermore, the introduction of glutamate improved the hydrophilicity of 4A-PLGA, thus effectively promoting cell entry and adhesion, which makes the electrospun 4A-PLGA-PGPE membranes promising for tissue engineering.

Original languageEnglish
Pages (from-to)2428-2436
Number of pages9
JournalACS Biomaterial Science and Engineering
Volume8
Issue number6
Early online date19 May 2022
DOIs
Publication statusPublished - 13 Jun 2022

Keywords

  • DRUG-DELIVERY
  • IN-VITRO
  • L-LACTIDE
  • NANOFIBERS
  • NANOPARTICLES
  • PLGA MICROSPHERES
  • RING-OPENING POLYMERIZATION
  • SCAFFOLD
  • SURFACE MODIFICATION
  • VIVO
  • copolymer
  • electrospun membrane
  • four-armed poly(lactide-co-glycolide)
  • glutamic acid
  • hydrophilic modification

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