Abstract
Common poly(lactide-co-glycolide) (i-PLGA) has emerged as a biodegradable and biocompatible material in tissue engineering. However, the poor hydrophilicity and elasticity of i-PLGA lead to its limited application in tissue engineering. To this end, an amphiphilic crosslinked four-armed poly(lactic-co-glycolide) was prepared. First, four-armed PLGA (4A-PLGA) was synthesized by polymerizing l-lactide (LA) and glycolide (GA) with pentaerythritol as the initiator. Then, the hydrophilic polymer poly(glutamate propylene ester) (PGPE) was prepared through the esterification of glutamic acid and 1,2-propanediol. The hydrophilic 4A-PLGA-PGPE was finally synthesized through the condensation reaction of 4A-PLGA and PGPE with the aid of triphosgene. 4A-PLGA-PGPE was then used to prepare amphiphilic membranes by electrospinning. It was demonstrated that the mechanical properties and biocompatibility of 4A-PLGA were improved after the introduction of PGPE. Furthermore, the introduction of glutamate improved the hydrophilicity of 4A-PLGA, thus effectively promoting cell entry and adhesion, which makes the electrospun 4A-PLGA-PGPE membranes promising for tissue engineering.
Original language | English |
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Pages (from-to) | 2428-2436 |
Number of pages | 9 |
Journal | ACS Biomaterial Science and Engineering |
Volume | 8 |
Issue number | 6 |
Early online date | 19 May 2022 |
DOIs | |
Publication status | Published - 13 Jun 2022 |
Keywords
- DRUG-DELIVERY
- IN-VITRO
- L-LACTIDE
- NANOFIBERS
- NANOPARTICLES
- PLGA MICROSPHERES
- RING-OPENING POLYMERIZATION
- SCAFFOLD
- SURFACE MODIFICATION
- VIVO
- copolymer
- electrospun membrane
- four-armed poly(lactide-co-glycolide)
- glutamic acid
- hydrophilic modification