Amino acid metabolism, transport and signalling in the liver revisited

Coen C Paulusma, Wouter H Lamers, Stefan Broer, Stan F J van de Graaf*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

The liver controls the systemic exposure of amino acids entering via the gastro-intestinal tract. For most amino acids except branched chain amino acids, hepatic uptake is very efficient. This implies that the liver orchestrates amino acid metabolism and also controls systemic amino acid exposure. Although many amino acid transporters have been identified, cloned and investigated with respect to substrate specificity, transport mechanism, and zonal distribution, which of these players are involved in hepatocellular amino acid transport remains unclear. Here, we aim to provide a review of current insight into the molecular machinery of hepatic amino acid transport. Furthermore, we place this information in a comprehensive overview of amino acid transport, signalling and metabolism.

Original languageEnglish
Article number115074
Number of pages16
JournalBiochemical Pharmacology
Volume201
Early online date11 May 2022
DOIs
Publication statusPublished - Jul 2022

Keywords

  • Amino acid signalling
  • Amino acid transport
  • DIGITONIN COLLAGENASE PERFUSION
  • GENE-EXPRESSION
  • GLUTAMINE-SYNTHETASE
  • Gluconeogenesis
  • HEPATOCELLULAR-CARCINOMA
  • Hepatocyte
  • Liver
  • MESSENGER-RNA
  • Metabolic zonation
  • NITROGEN-METABOLISM
  • RAT-LIVER
  • SKELETAL-MUSCLE
  • SPLANCHNIC BED UTILIZATION
  • SYSTEM-A
  • mTORC1

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