Amalaki Rasayana improved memory and neuronal metabolic activity in AbPP-PS1 mouse model of Alzheimer's disease

Vivek Tiwari, Kamal Saba, Pandichelvam Veeraiah, Jedy Jose, Subhash C Lakhotia, Anant B Patel*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Alzheimer's disease (AD) is the most common neurodegenerative disorder characterized by progressive loss of memory and cognitive function. The cerebral metabolic rate of glucose oxidation has been shown to be reduced in AD. The present study evaluated efficacy of dietary Amalaki Rasayana (AR), an Ayurvedic formulation used in Indian traditional system, in AbPP-PS1 mouse model of AD in ameliorating memory and neurometabolism, and compared with donepezil, a standard FDA approved drug for AD. The memory of mice was measured using Morris Water Maze analysis. The cerebral metabolism was followed by 13C labelling of brain amino acids in tissue extracts ex vivo using 1H-[13C]-NMR spectroscopy together with a short time infusion of [1,6-13C2]glucose to mice. The intervention with Amalaki Rasayana showed improved learning and memory in AbPP-PS1 mice. The 13C labelings of GluC4, GABAC2 and GlnC4 were reduced in AbPP-PS1 mice when compared with wild-type controls. Intervention of AR increased the 13C labelling of amino acids suggesting a significant enhancement in glutamatergic and GABAergic metabolic activity in AbPP-PS1 mice similar to that observed with donepezil treatment. These data suggest that AR has potential to improve memory and cognitive function in AD.

Original languageEnglish
Pages (from-to)363-371
Number of pages9
JournalJournal of Biosciences
Issue number3
Publication statusPublished - Sept 2017
Externally publishedYes


  • Alzheimer Disease/drug therapy
  • Amyloid beta-Protein Precursor/genetics
  • Animals
  • Brain/drug effects
  • Carbon Isotopes
  • Cognition/drug effects
  • Donepezil
  • Gene Expression
  • Glucose/metabolism
  • Glutamic Acid/metabolism
  • Glutamine/metabolism
  • Humans
  • Indans/pharmacology
  • Male
  • Maze Learning/drug effects
  • Medicine, Ayurvedic/methods
  • Memory/drug effects
  • Mice
  • Mice, Transgenic
  • Neurons/drug effects
  • Neuroprotective Agents/pharmacology
  • Piperidines/pharmacology
  • Plant Extracts/pharmacology
  • Presenilin-1/genetics
  • gamma-Aminobutyric Acid/metabolism


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