Alternative Pharmacologic Therapy for Aggressive Central Giant Cell Granuloma: Denosumab

Willem H. Schreuder*, Annet W. Coumou, Peter A. H. W. Kessler, Jan de lange

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

35 Citations (Web of Science)


In the search for new pharmacologic therapies for central giant cell granuloma (CGCG), proteins that are essential to osteoclastogenesis are intriguing potential targets. In the present case report, we describe a 25-year-old patient with an aggressive CGCG of the maxilla, who was successfully treated with the antiresorptive agent denosumab, after other pharmacologic treatment had failed to achieve regression or stabilization of the tumor. Denosumab could be a promising alternative to potentially mutilating surgery for CGCG. However, more research is needed before definite conclusions can be drawn about the potential role of this agent in the treatment of CGCG.
Original languageEnglish
Pages (from-to)1301-1309
JournalJournal of Oral and Maxillofacial Surgery
Issue number7
Publication statusPublished - Jul 2014

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