TY - JOUR
T1 - Alternative Pharmacologic Therapy for Aggressive Central Giant Cell Granuloma: Denosumab
AU - Schreuder, Willem H.
AU - Coumou, Annet W.
AU - Kessler, Peter A. H. W.
AU - de lange, Jan
PY - 2014/7
Y1 - 2014/7
N2 - In the search for new pharmacologic therapies for central giant cell granuloma (CGCG), proteins that are essential to osteoclastogenesis are intriguing potential targets. In the present case report, we describe a 25-year-old patient with an aggressive CGCG of the maxilla, who was successfully treated with the antiresorptive agent denosumab, after other pharmacologic treatment had failed to achieve regression or stabilization of the tumor. Denosumab could be a promising alternative to potentially mutilating surgery for CGCG. However, more research is needed before definite conclusions can be drawn about the potential role of this agent in the treatment of CGCG.
AB - In the search for new pharmacologic therapies for central giant cell granuloma (CGCG), proteins that are essential to osteoclastogenesis are intriguing potential targets. In the present case report, we describe a 25-year-old patient with an aggressive CGCG of the maxilla, who was successfully treated with the antiresorptive agent denosumab, after other pharmacologic treatment had failed to achieve regression or stabilization of the tumor. Denosumab could be a promising alternative to potentially mutilating surgery for CGCG. However, more research is needed before definite conclusions can be drawn about the potential role of this agent in the treatment of CGCG.
U2 - 10.1016/j.joms.2014.02.017
DO - 10.1016/j.joms.2014.02.017
M3 - Article
C2 - 24835517
SN - 0278-2391
VL - 72
SP - 1301
EP - 1309
JO - Journal of Oral and Maxillofacial Surgery
JF - Journal of Oral and Maxillofacial Surgery
IS - 7
ER -