Altered glutamate metabolism is associated with reduced muscle glutathione levels in patients with emphysema

M.P.K.J. Engelen, A.M.W.J. Schols, J. Does, N.E.P. Deutz, E.F.M. Wouters

Research output: Contribution to journalArticleAcademicpeer-review

84 Citations (Scopus)

Abstract

Chronic obstructive pulmonary disease (COPD) is often characterized by an impaired skeletal muscle energy metabolism, which is at least partly related to chronic hypoxia and a reduced diffusing capacity. We have found that muscle glutamate (Glu), which is negatively influenced by these conditions, was reduced in patients with severe COPD. The aim of this study was to investigate whether the reduced intracellular Glu level in patients with emphysema is associated with an increased muscle glycolytic metabolism Since Glu is an important substrate in the synthesis of glutamine (Gln) and glutathione (GSH), the influence of Glu status on muscle GSH and Gln was also examined. In 13 patients with emphysema and 25 control patients, arterial blood and biopsies from the vastus lateralis muscle were obtained. Expressed as a percentage of the control values, the patients with emphysema had reduced values for muscle Glu (64 +/- 12%; p levels.
Original languageEnglish
Pages (from-to)98-103
Number of pages6
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume161
Issue number98
DOIs
Publication statusPublished - 1 Jan 2000

Cite this