Altered Connectivity of the Frontoparietal Network During Attention Processing in Prolactinomas

Chenglong Cao; Y. Wang; J. Liu; A.B. Chen; J.J. Lu; G.Z. Xu; J. Song

doi:10.3389/fneur.2021.638851

Altered Connectivity of the Frontoparietal Network During Attention Processing in Prolactinomas

Chenglong Cao, Y. Wang, J. Liu, A.B. Chen, J.J. Lu, G.Z. Xu^*, J. Song^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Prolactinomas have been reported for the failure of cognitive functions. However, the electrophysiological mechanisms of attention processing in prolactinomas remain unclear. In a visual mission, we monitored the scalp electroencephalography (EEG) of the participants. Compared with the healthy controls (HCs), larger frontoparietal theta and alpha coherence were found in the patients, especially in the right-lateralized hemisphere, which indicated a deficit in attention processing. Moreover, the frontoparietal coherence was positively correlated with altered prolactin (PRL) levels, implying the significance of PRL for adaptive brain compensation in prolactinomas. Taken together, this research showed the variations in attention processing between the HCs and prolactinomas. The coherence between frontal and parietal regions may be one of the possible electrophysiological biomarkers for detecting deficient attention processing in prolactinomas.</p>

Original language	English
Article number	638851
Number of pages	9
Journal	Frontiers in Neurology
Volume	12
DOIs	https://doi.org/10.3389/fneur.2021.638851
Publication status	Published - 30 Aug 2021

Keywords

prolactinomas
attention processing
prolactin
theta coherence
alpha coherence
COGNITIVE DYSFUNCTION
PITUITARY PATIENTS
NEGATIVITY BIAS
WHITE-MATTER
BRAIN
HYPERPROLACTINEMIA
TESTOSTERONE
EXPRESSION
DIAGNOSIS
EMOTION

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Cite this

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title = "Altered Connectivity of the Frontoparietal Network During Attention Processing in Prolactinomas",

abstract = "Prolactinomas have been reported for the failure of cognitive functions. However, the electrophysiological mechanisms of attention processing in prolactinomas remain unclear. In a visual mission, we monitored the scalp electroencephalography (EEG) of the participants. Compared with the healthy controls (HCs), larger frontoparietal theta and alpha coherence were found in the patients, especially in the right-lateralized hemisphere, which indicated a deficit in attention processing. Moreover, the frontoparietal coherence was positively correlated with altered prolactin (PRL) levels, implying the significance of PRL for adaptive brain compensation in prolactinomas. Taken together, this research showed the variations in attention processing between the HCs and prolactinomas. The coherence between frontal and parietal regions may be one of the possible electrophysiological biomarkers for detecting deficient attention processing in prolactinomas.",

keywords = "prolactinomas, attention processing, prolactin, theta coherence, alpha coherence, COGNITIVE DYSFUNCTION, PITUITARY PATIENTS, NEGATIVITY BIAS, WHITE-MATTER, BRAIN, HYPERPROLACTINEMIA, TESTOSTERONE, EXPRESSION, DIAGNOSIS, EMOTION",

author = "Chenglong Cao and Y. Wang and J. Liu and A.B. Chen and J.J. Lu and G.Z. Xu and J. Song",

note = "Funding Information: Funding. This work was supported by funding from the National Natural Science Foundation of China (81571049 and 81870863) and the Chinese Scholarship Council (202008440671). Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Cao, Wang, Liu, Chen, Lu, Xu and Song.",

year = "2021",

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day = "30",

doi = "10.3389/fneur.2021.638851",

language = "English",

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AU - Cao, Chenglong

AU - Wang, Y.

AU - Liu, J.

AU - Chen, A.B.

AU - Lu, J.J.

AU - Xu, G.Z.

AU - Song, J.

N1 - Funding Information: Funding. This work was supported by funding from the National Natural Science Foundation of China (81571049 and 81870863) and the Chinese Scholarship Council (202008440671). Publisher Copyright: © Copyright © 2021 Cao, Wang, Liu, Chen, Lu, Xu and Song.

PY - 2021/8/30

Y1 - 2021/8/30

N2 - Prolactinomas have been reported for the failure of cognitive functions. However, the electrophysiological mechanisms of attention processing in prolactinomas remain unclear. In a visual mission, we monitored the scalp electroencephalography (EEG) of the participants. Compared with the healthy controls (HCs), larger frontoparietal theta and alpha coherence were found in the patients, especially in the right-lateralized hemisphere, which indicated a deficit in attention processing. Moreover, the frontoparietal coherence was positively correlated with altered prolactin (PRL) levels, implying the significance of PRL for adaptive brain compensation in prolactinomas. Taken together, this research showed the variations in attention processing between the HCs and prolactinomas. The coherence between frontal and parietal regions may be one of the possible electrophysiological biomarkers for detecting deficient attention processing in prolactinomas.

AB - Prolactinomas have been reported for the failure of cognitive functions. However, the electrophysiological mechanisms of attention processing in prolactinomas remain unclear. In a visual mission, we monitored the scalp electroencephalography (EEG) of the participants. Compared with the healthy controls (HCs), larger frontoparietal theta and alpha coherence were found in the patients, especially in the right-lateralized hemisphere, which indicated a deficit in attention processing. Moreover, the frontoparietal coherence was positively correlated with altered prolactin (PRL) levels, implying the significance of PRL for adaptive brain compensation in prolactinomas. Taken together, this research showed the variations in attention processing between the HCs and prolactinomas. The coherence between frontal and parietal regions may be one of the possible electrophysiological biomarkers for detecting deficient attention processing in prolactinomas.

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