Altered Connectivity of the Frontoparietal Network During Attention Processing in Prolactinomas

Chenglong Cao, Y. Wang, J. Liu, A.B. Chen, J.J. Lu, G.Z. Xu*, J. Song*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Prolactinomas have been reported for the failure of cognitive functions. However, the electrophysiological mechanisms of attention processing in prolactinomas remain unclear. In a visual mission, we monitored the scalp electroencephalography (EEG) of the participants. Compared with the healthy controls (HCs), larger frontoparietal theta and alpha coherence were found in the patients, especially in the right-lateralized hemisphere, which indicated a deficit in attention processing. Moreover, the frontoparietal coherence was positively correlated with altered prolactin (PRL) levels, implying the significance of PRL for adaptive brain compensation in prolactinomas. Taken together, this research showed the variations in attention processing between the HCs and prolactinomas. The coherence between frontal and parietal regions may be one of the possible electrophysiological biomarkers for detecting deficient attention processing in prolactinomas.</p>
Original languageEnglish
Article number638851
Number of pages9
JournalFrontiers in Neurology
Volume12
DOIs
Publication statusPublished - 30 Aug 2021

Keywords

  • prolactinomas
  • attention processing
  • prolactin
  • theta coherence
  • alpha coherence
  • COGNITIVE DYSFUNCTION
  • PITUITARY PATIENTS
  • NEGATIVITY BIAS
  • WHITE-MATTER
  • BRAIN
  • HYPERPROLACTINEMIA
  • TESTOSTERONE
  • EXPRESSION
  • DIAGNOSIS
  • EMOTION

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