Altered Cellular Metabolism Drives Trained Immunity

Yahya Sohrabi; Rinesh Godfrey; Hannes M. Findeisen

doi:10.1016/j.tem.2018.03.012

Altered Cellular Metabolism Drives Trained Immunity

Yahya Sohrabi^*, Rinesh Godfrey, Hannes M. Findeisen^*

^*Corresponding author for this work

Fysiologie

Research output: Contribution to journal › Editorial › Academic › peer-review

Abstract

Exposing innate immune cells to an initial insult induces a long-term proinflammatory response due to metabolic and epigenetic alterations which encompass an emerging new concept called trained immunity. Recent studies provide novel insights into mechanisms centered on metabolic reprogramming which induce innate immune memory in hematopoietic stem cells and monocytes.

Original language	English
Pages (from-to)	602-605
Number of pages	5
Journal	Trends in Endocrinology and Metabolism
Volume	29
Issue number	9
DOIs	https://doi.org/10.1016/j.tem.2018.03.012
Publication status	Published - 1 Sept 2018

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INDUCTION

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title = "Altered Cellular Metabolism Drives Trained Immunity",

abstract = "Exposing innate immune cells to an initial insult induces a long-term proinflammatory response due to metabolic and epigenetic alterations which encompass an emerging new concept called trained immunity. Recent studies provide novel insights into mechanisms centered on metabolic reprogramming which induce innate immune memory in hematopoietic stem cells and monocytes.",

keywords = "INDUCTION",

author = "Yahya Sohrabi and Rinesh Godfrey and Findeisen, {Hannes M.}",

year = "2018",

month = sep,

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doi = "10.1016/j.tem.2018.03.012",

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T1 - Altered Cellular Metabolism Drives Trained Immunity

AU - Sohrabi, Yahya

AU - Godfrey, Rinesh

AU - Findeisen, Hannes M.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Exposing innate immune cells to an initial insult induces a long-term proinflammatory response due to metabolic and epigenetic alterations which encompass an emerging new concept called trained immunity. Recent studies provide novel insights into mechanisms centered on metabolic reprogramming which induce innate immune memory in hematopoietic stem cells and monocytes.

AB - Exposing innate immune cells to an initial insult induces a long-term proinflammatory response due to metabolic and epigenetic alterations which encompass an emerging new concept called trained immunity. Recent studies provide novel insights into mechanisms centered on metabolic reprogramming which induce innate immune memory in hematopoietic stem cells and monocytes.

KW - INDUCTION

U2 - 10.1016/j.tem.2018.03.012

DO - 10.1016/j.tem.2018.03.012

M3 - Editorial

SN - 1043-2760

VL - 29

SP - 602

EP - 605

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 9

ER -

Altered Cellular Metabolism Drives Trained Immunity

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