alpha-Linolenic acid and exercise training independently, and additively, decrease blood pressure and prevent diastolic dysfunction in obese Zucker rats

Pierre-Andre Barbeau, Tanya M. Holloway, Jamie Whitfield, Brittany L. Baechler, Joe Quadrilatero, Luc J. C. van Loon, Adrian Chabowski, Graham P. Holloway*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Web of Science)

Abstract

Although alpha-linolenic acid (ALA) and endurance exercise training independently attenuate hyperlipidaemia-related cardiovascular derangements, there is a paucity of information pertaining to their mechanisms of action and efficacy when combined as a preventative therapeutic approach. Therefore, we used obese Zucker rats to investigate the independent and combined effects of these interventions on cardiovascular disease. Specifically, animals were randomly assigned to one of the following groups: control diet-sedentary, ALA supplemented-sedentary, control diet-exercise trained or ALA supplemented-exercise trained. Following a 4week intervention, although the independent and combined effects of ALA and exercise reduced (P

Original languageEnglish
Pages (from-to)4351-4364
Number of pages14
JournalJournal of Physiology
Volume595
Issue number13
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • angiogenesis
  • diabetic cardiomyopathy
  • exercise physiology
  • heart
  • PUFA
  • CORONARY-HEART-DISEASE
  • N-3 FATTY-ACIDS
  • DIABETIC CARDIOMYOPATHY
  • METABOLIC SYNDROME
  • LIPID PROFILE
  • FISH-OIL
  • MITOCHONDRIAL BIOGENESIS
  • INSULIN-RESISTANCE
  • SERUM-CHOLESTEROL
  • PHYSICAL-EXERCISE

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