Abstract
Although alpha-linolenic acid (ALA) and endurance exercise training independently attenuate hyperlipidaemia-related cardiovascular derangements, there is a paucity of information pertaining to their mechanisms of action and efficacy when combined as a preventative therapeutic approach. Therefore, we used obese Zucker rats to investigate the independent and combined effects of these interventions on cardiovascular disease. Specifically, animals were randomly assigned to one of the following groups: control diet-sedentary, ALA supplemented-sedentary, control diet-exercise trained or ALA supplemented-exercise trained. Following a 4week intervention, although the independent and combined effects of ALA and exercise reduced (P
Original language | English |
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Pages (from-to) | 4351-4364 |
Number of pages | 14 |
Journal | Journal of Physiology |
Volume | 595 |
Issue number | 13 |
DOIs | |
Publication status | Published - 1 Jul 2017 |
Keywords
- angiogenesis
- diabetic cardiomyopathy
- exercise physiology
- heart
- PUFA
- CORONARY-HEART-DISEASE
- N-3 FATTY-ACIDS
- DIABETIC CARDIOMYOPATHY
- METABOLIC SYNDROME
- LIPID PROFILE
- FISH-OIL
- MITOCHONDRIAL BIOGENESIS
- INSULIN-RESISTANCE
- SERUM-CHOLESTEROL
- PHYSICAL-EXERCISE