@article{c5e444a9e33d4f92a25d40f6b2e7c315,
title = "Allotransplantation for Patients Age >= 40 Years with Non-Hodgkin Lymphoma: Encouraging Progression-Free Survival",
abstract = "Non-Hodgkin lymphoma (NHL) disproportionately affects older patients, who do not often undergo allogeneic hematopoietic cell transplantation (HCT). We analyzed Center for International Blood and Marrow Transplant Research data on 1248 patients age ?40 years receiving reduced-intensity conditioning (RIC) or nonmyeloablative (NMA) conditioning HCT for aggressive (n = 668) or indolent (n = 580) NHL. Aggressive lymphoma was more frequent in the oldest cohort 49% for age 40 to 54 versus 57% for age 55 to 64 versus 67% for age ?65; P = .0008). Fewer patients aged ?65 had previous autografting (26% versus 24% versus 9%; P = .002). Rates of relapse, acute and chronic GVHD, and nonrelapse mortality (NRM) at 1 year post-HCT were similar in the 3 age cohorts (22% [95% confidence interval (CI), 19% to 26%] for age 40 to 54, 27% [95% CI, 23% to 31%] for age 55 to 64, and 34% [95% CI, 24% to 44%] for age ?65. Progression-free survival (PFS) and overall survival (OS) at 3 years was slightly lower in the older cohorts (OS: 54% [95% CI, 50% to 58%] for age 40 to 54; 40% [95% CI, 36% to 44%] for age 55 to 64, and 39% [95% CI, 28% to 50%] for age ?65; P <.0001). Multivariate analysis revealed no significant effect of age on the incidence of acute or chronic GVHD or relapse. Age ?55 years, Karnofsky Performance Status ",
keywords = "Reduced intensity, Nonmyeloablative, Allogeneic, Hematopoietic cell transplantation, Elderly, Lymphoma",
author = "McClune, {Brian L.} and Ahn, {Kwang Woo} and Hai-Lin Wang and Antin, {Joseph H.} and Artz, {Andrew S.} and Jean-Yves Cahn and Abhinav Deol and Freytes, {Cesar O.} and Mehdi Hamadani and Holmberg, {Leona A.} and Jagasia, {Madan H.} and Jakubowski, {Ann A.} and Kharfan-Dabaja, {Mohamed A.} and Lazarus, {Hillard M.} and Miller, {Alan M.} and Richard Olsson and Pedersen, {Tanya L.} and Joseph Pidala and Pulsipher, {Michael A.} and Rowe, {Jacob M.} and Wael Saber and {van Besien}, {Koen W.} and Waller, {Edmund K.} and Aljurf, {Mahmoud D.} and Goergun Akpek and Ulrike Bacher and Chao, {Nelson J.} and Yi-Bin Chen and Cooper, {Brenda W.} and Jason Dehn and {de Lima}, {Marcos J.} and Hsu, {Jack W.} and Lewis, {Ian D.} and Marks, {David I.} and Joseph McGuirk and Cairo, {Mitchell S.} and Schouten, {Harry C.} and Jeffrey Szer and Muthalagu Ramanathan and Savani, {Bipin N.} and Matthew Seftel and Gerard Socie and Ravi Vij and Warlick, {Erica D.} and Weisdorf, {Daniel J.}",
year = "2014",
month = jul,
doi = "10.1016/j.bbmt.2014.03.013",
language = "English",
volume = "20",
pages = "960--968",
journal = "Biology of Blood and Marrow Transplantation",
issn = "1083-8791",
publisher = "Elsevier Inc.",
number = "7",
}