Allogeneic stem cell transplantation in AML with t(6;9)(p23;q34);DEK-NUP214 shows a favourable outcome when performed in first complete remission

M. Diaz-Beya, M. Labopin, J. Maertens, M. Alijurf, J. Passweg, B. Dietrich, H. Schouten, G. Socie, N. Schaap, R. Schwerdtfeger, L. Volin, M. Michallet, E. Polge, J. Sierra, M. Mohty, J. Esteve*, A. Nagler, European Society for Blood and Marrow Transplantation Lymphoma and Chronic Malignancies Working Parties

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Web of Science)

Abstract

Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is a poor-risk entity, commonly associated with FLT3-ITD (internal tandem duplication). Allogeneic stem-cell tranplantation (allo-SCT) is recommended, although studies analysing the outcome of allo-SCT in this setting are lacking. We selected 195 patients with t(6;9) AML, who received a first allo-SCT between 2000 and 2016 from the EBMT (European Society for Blood and Marrow Transplantation) registry. Disease status at time of allo-SCT was the strongest independent prognostic factor, with a two-year leukaemia-free survival and relapse incidence of 57% and 19% in patients in CR1 (first complete remission), 34% and 33% in CR2 (second complete remission), and 24% and 49% in patients not in remission, respectively (P < 0 center dot 001). This study, which represents the largest one available in t(6;9) AML, supports the recommendation to submit these patients to allo-SCT in CR1.

Original languageEnglish
Pages (from-to)920-925
Number of pages6
JournalBritish Journal of Haematology
Volume189
Issue number5
DOIs
Publication statusPublished - 1 Jun 2020

Keywords

  • 9) aml
  • acute myeloid-leukemia
  • allo-sct
  • aml
  • blood
  • classification
  • dek-nup214
  • european-society
  • internal tandem duplication
  • prognosis
  • t(6
  • working party
  • AML
  • INTERNAL TANDEM DUPLICATION
  • 9) AML
  • PROGNOSIS
  • CLASSIFICATION
  • ACUTE MYELOID-LEUKEMIA
  • EUROPEAN-SOCIETY
  • WORKING PARTY
  • allo-SCT
  • DEK-NUP214
  • BLOOD

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