TY - JOUR
T1 - Alexithymia, suicide ideation, affective temperaments and homocysteine levels in drug naïve patients with post-traumatic stress disorder: an exploratory study in the everyday ‘real world’ clinical practice
T2 - an exploratory study in the everyday 'real world' clinical practice
AU - De Berardis, Domenico
AU - Vellante, Federica
AU - Fornaro, Michele
AU - Anastasia, Annalisa
AU - Olivieri, Luigi
AU - Rapini, Gabriella
AU - Serroni, Nicola
AU - Orsolini, Laura
AU - Valchera, Alessandro
AU - Carano, Alessandro
AU - Tomasetti, Carmine
AU - Varasano, Paola Annunziata
AU - Pressanti, Gabriella Lucidi
AU - Bustini, Massimiliano
AU - Pompili, Maurizio
AU - Serafini, Gianluca
AU - Perna, Giampaolo
AU - Martinotti, Giovanni
AU - Di Giannantonio, Massimo
PY - 2020/1/2
Y1 - 2020/1/2
N2 - Objective: The present exploratory study aimed to investigate relationships between alexithymia, suicide ideation, affective temperaments and homocysteine levels among drug-naive adult outpatients with Post-Traumatic Stress Disorder (PTSD) in an everyday 'real world' clinical setting. Method: Sixty-four adult outpatients with PTSD were evaluated using the Davidson Trauma Scale (DTS), the Toronto Alexithymia Scale (TAS-20), the Scale of Suicide Ideation (SSI), the Temperament Evaluation of the Memphis, Pisa, Paris and San Diego-Autoquestionnaire. As well, homocysteine levels were measured. Results: Alexithymic subjects showed higher values on all scales but not homocysteine levels. Partial correlations showed that almost all studied variables were correlated with each other, except homocysteine levels. Regression analysis showed that higher disorder severity as measured by DTS and TAS-20 'Difficulty in Identifying Feelings' dimension was associated with higher SSI scores. Conclusions: In conclusion, alexithymic PTSD outpatients may be characterised by higher disorder severity and difficulty in identifying feelings that may be linked to increased suicide ideation, regardless of affective temperaments or homocysteine levels. Homocysteine levels were not related to any studied variable. However, study limitations are discussed and must be considered.Keypoints Patients with alexithymia showed increased PTSD severity, a higher score on TEMPS-A subscales, and more severe suicide ideation. The Difficulty in Identifying Feelings (DIF) dimension of TAS-20 was associated with suicide ideation in patients with PTSD. Homocysteine did not correlate with any studied variables. This study was exploratory and cross-sectional: further larger and prospective studies are needed.
AB - Objective: The present exploratory study aimed to investigate relationships between alexithymia, suicide ideation, affective temperaments and homocysteine levels among drug-naive adult outpatients with Post-Traumatic Stress Disorder (PTSD) in an everyday 'real world' clinical setting. Method: Sixty-four adult outpatients with PTSD were evaluated using the Davidson Trauma Scale (DTS), the Toronto Alexithymia Scale (TAS-20), the Scale of Suicide Ideation (SSI), the Temperament Evaluation of the Memphis, Pisa, Paris and San Diego-Autoquestionnaire. As well, homocysteine levels were measured. Results: Alexithymic subjects showed higher values on all scales but not homocysteine levels. Partial correlations showed that almost all studied variables were correlated with each other, except homocysteine levels. Regression analysis showed that higher disorder severity as measured by DTS and TAS-20 'Difficulty in Identifying Feelings' dimension was associated with higher SSI scores. Conclusions: In conclusion, alexithymic PTSD outpatients may be characterised by higher disorder severity and difficulty in identifying feelings that may be linked to increased suicide ideation, regardless of affective temperaments or homocysteine levels. Homocysteine levels were not related to any studied variable. However, study limitations are discussed and must be considered.Keypoints Patients with alexithymia showed increased PTSD severity, a higher score on TEMPS-A subscales, and more severe suicide ideation. The Difficulty in Identifying Feelings (DIF) dimension of TAS-20 was associated with suicide ideation in patients with PTSD. Homocysteine did not correlate with any studied variables. This study was exploratory and cross-sectional: further larger and prospective studies are needed.
KW - Alexithymia
KW - post-traumatic stress disorder
KW - suicide ideation
KW - temperaments
KW - homocysteine
KW - feelings
KW - SERUM-LIPID LEVELS
KW - COGNITIVE DECLINE
KW - MAJOR DEPRESSION
KW - PTSD
KW - METAANALYSIS
KW - SCALE
KW - RISK
KW - ASSOCIATION
KW - CHARACTER
KW - SYMPTOMS
U2 - 10.1080/13651501.2019.1699575
DO - 10.1080/13651501.2019.1699575
M3 - Article
C2 - 31829763
SN - 1365-1501
VL - 24
SP - 83
EP - 87
JO - International Journal of Psychiatry in Clinical Practice
JF - International Journal of Psychiatry in Clinical Practice
IS - 1
ER -