Alexithymia, suicide ideation, affective temperaments and homocysteine levels in drug naïve patients with post-traumatic stress disorder: an exploratory study in the everyday ‘real world’ clinical practice: an exploratory study in the everyday 'real world' clinical practice

Domenico De Berardis*, Federica Vellante, Michele Fornaro, Annalisa Anastasia, Luigi Olivieri, Gabriella Rapini, Nicola Serroni, Laura Orsolini, Alessandro Valchera, Alessandro Carano, Carmine Tomasetti, Paola Annunziata Varasano, Gabriella Lucidi Pressanti, Massimiliano Bustini, Maurizio Pompili, Gianluca Serafini, Giampaolo Perna, Giovanni Martinotti, Massimo Di Giannantonio

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Objective: The present exploratory study aimed to investigate relationships between alexithymia, suicide ideation, affective temperaments and homocysteine levels among drug-naive adult outpatients with Post-Traumatic Stress Disorder (PTSD) in an everyday 'real world' clinical setting. Method: Sixty-four adult outpatients with PTSD were evaluated using the Davidson Trauma Scale (DTS), the Toronto Alexithymia Scale (TAS-20), the Scale of Suicide Ideation (SSI), the Temperament Evaluation of the Memphis, Pisa, Paris and San Diego-Autoquestionnaire. As well, homocysteine levels were measured. Results: Alexithymic subjects showed higher values on all scales but not homocysteine levels. Partial correlations showed that almost all studied variables were correlated with each other, except homocysteine levels. Regression analysis showed that higher disorder severity as measured by DTS and TAS-20 'Difficulty in Identifying Feelings' dimension was associated with higher SSI scores. Conclusions: In conclusion, alexithymic PTSD outpatients may be characterised by higher disorder severity and difficulty in identifying feelings that may be linked to increased suicide ideation, regardless of affective temperaments or homocysteine levels. Homocysteine levels were not related to any studied variable. However, study limitations are discussed and must be considered.Keypoints Patients with alexithymia showed increased PTSD severity, a higher score on TEMPS-A subscales, and more severe suicide ideation. The Difficulty in Identifying Feelings (DIF) dimension of TAS-20 was associated with suicide ideation in patients with PTSD. Homocysteine did not correlate with any studied variables. This study was exploratory and cross-sectional: further larger and prospective studies are needed.

Original languageEnglish
Pages (from-to)83-87
Number of pages5
JournalInternational Journal of Psychiatry in Clinical Practice
Issue number1
Early online date11 Dec 2019
Publication statusPublished - 2 Jan 2020


  • Alexithymia
  • post-traumatic stress disorder
  • suicide ideation
  • temperaments
  • homocysteine
  • feelings
  • PTSD
  • RISK

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