Alcohol Consumption and Common Carotid Intima-Media Thickness: The USE-IMT Study

Annie R. Britton; Diederick E. Grobbee; Hester M. den Ruijter; Todd J. Anderson; Moise Desvarieux; Gunnar Engstrom; Greg W. Evans; Bo Hedblad; Jussi Kauhanen; Sudhir Kurl; Eva M. Lonn; Ellisiv B. Mathiesen; Joseph F. Polak; Jacqueline F. Price; Christopher M. Rembold; Maria Rosvall; Tatjana Rundek; Jukka T. Salonen; Coen Stehouwer; Tomi-Pekka Tuomainen; Michiel L. Bots

doi:10.1093/alcalc/agx028

Alcohol Consumption and Common Carotid Intima-Media Thickness: The USE-IMT Study

Annie R. Britton^*, Diederick E. Grobbee, Hester M. den Ruijter, Todd J. Anderson, Moise Desvarieux, Gunnar Engstrom, Greg W. Evans, Bo Hedblad, Jussi Kauhanen, Sudhir Kurl, Eva M. Lonn, Ellisiv B. Mathiesen, Joseph F. Polak, Jacqueline F. Price, Christopher M. Rembold, Maria Rosvall, Tatjana Rundek, Jukka T. Salonen, Coen Stehouwer, Tomi-Pekka TuomainenMichiel L. Bots

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Epidemiological evidence indicates a protective effect of light to moderate alcohol consumption compared to non-drinking and heavy drinking. Although several mechanisms have been suggested, the effect of alcohol on atherosclerotic changes in vessel walls is unclear. Therefore, we explored the relationship between alcohol consumption and common carotid intima media thickness, a marker of early atherosclerosis in the general population.

Individual participant data from eight cohorts, involving 37,494 individuals from the USE-IMT collaboration were used. Multilevel age and sex adjusted linear regression models were applied to estimate mean differences in common carotid intima-media thickness (CIMT) with alcohol consumption.

The mean age was 57.9 years (SD 8.6) and the mean CIMT was 0.75 mm (SD 0.177). About, 40.5% reported no alcohol consumed, and among those who drank, mean consumption was 13.3 g per day (SD 16.4). Those consuming no alcohol or a very small amount (<5 g per day) had significantly lower common CIMT values than those consuming > 10 g per day, after adjusting for a range of confounding factors.

In this large CIMT consortium, we did not find evidence to support a protective effect of alcohol on CIMT.

Original language	English
Pages (from-to)	483-486
Number of pages	4
Journal	Alcohol and Alcoholism
Volume	52
Issue number	4
DOIs	https://doi.org/10.1093/alcalc/agx028
Publication status	Published - Jul 2017

Keywords

ARTERY STRUCTURE
ATHEROSCLEROSIS
RISK
MODERATE
ADULTS
HEALTH
OLDER
METAANALYSIS
ASSOCIATION
BENEFITS

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10.1093/alcalc/agx028Licence: CC BY

Cite this

Britton, A. R., Grobbee, D. E., den Ruijter, H. M., Anderson, T. J., Desvarieux, M., Engstrom, G., Evans, G. W., Hedblad, B., Kauhanen, J., Kurl, S., Lonn, E. M., Mathiesen, E. B., Polak, J. F., Price, J. F., Rembold, C. M., Rosvall, M., Rundek, T., Salonen, J. T., Stehouwer, C., ... Bots, M. L. (2017). Alcohol Consumption and Common Carotid Intima-Media Thickness: The USE-IMT Study. Alcohol and Alcoholism, 52(4), 483-486. https://doi.org/10.1093/alcalc/agx028

@article{8f07262241b74b43baecd5f24c620614,

title = "Alcohol Consumption and Common Carotid Intima-Media Thickness: The USE-IMT Study",

abstract = "Epidemiological evidence indicates a protective effect of light to moderate alcohol consumption compared to non-drinking and heavy drinking. Although several mechanisms have been suggested, the effect of alcohol on atherosclerotic changes in vessel walls is unclear. Therefore, we explored the relationship between alcohol consumption and common carotid intima media thickness, a marker of early atherosclerosis in the general population.Individual participant data from eight cohorts, involving 37,494 individuals from the USE-IMT collaboration were used. Multilevel age and sex adjusted linear regression models were applied to estimate mean differences in common carotid intima-media thickness (CIMT) with alcohol consumption.The mean age was 57.9 years (SD 8.6) and the mean CIMT was 0.75 mm (SD 0.177). About, 40.5% reported no alcohol consumed, and among those who drank, mean consumption was 13.3 g per day (SD 16.4). Those consuming no alcohol or a very small amount (<5 g per day) had significantly lower common CIMT values than those consuming > 10 g per day, after adjusting for a range of confounding factors.In this large CIMT consortium, we did not find evidence to support a protective effect of alcohol on CIMT.",

keywords = "ARTERY STRUCTURE, ATHEROSCLEROSIS, RISK, MODERATE, ADULTS, HEALTH, OLDER, METAANALYSIS, ASSOCIATION, BENEFITS",

author = "Britton, {Annie R.} and Grobbee, {Diederick E.} and {den Ruijter}, {Hester M.} and Anderson, {Todd J.} and Moise Desvarieux and Gunnar Engstrom and Evans, {Greg W.} and Bo Hedblad and Jussi Kauhanen and Sudhir Kurl and Lonn, {Eva M.} and Mathiesen, {Ellisiv B.} and Polak, {Joseph F.} and Price, {Jacqueline F.} and Rembold, {Christopher M.} and Maria Rosvall and Tatjana Rundek and Salonen, {Jukka T.} and Coen Stehouwer and Tomi-Pekka Tuomainen and Bots, {Michiel L.}",

year = "2017",

month = jul,

doi = "10.1093/alcalc/agx028",

language = "English",

volume = "52",

pages = "483--486",

journal = "Alcohol and Alcoholism",

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Britton, AR, Grobbee, DE, den Ruijter, HM, Anderson, TJ, Desvarieux, M, Engstrom, G, Evans, GW, Hedblad, B, Kauhanen, J, Kurl, S, Lonn, EM, Mathiesen, EB, Polak, JF, Price, JF, Rembold, CM, Rosvall, M, Rundek, T, Salonen, JT, Stehouwer, C, Tuomainen, T-P & Bots, ML 2017, 'Alcohol Consumption and Common Carotid Intima-Media Thickness: The USE-IMT Study', Alcohol and Alcoholism, vol. 52, no. 4, pp. 483-486. https://doi.org/10.1093/alcalc/agx028

TY - JOUR

T1 - Alcohol Consumption and Common Carotid Intima-Media Thickness

T2 - The USE-IMT Study

AU - Britton, Annie R.

AU - Grobbee, Diederick E.

AU - den Ruijter, Hester M.

AU - Anderson, Todd J.

AU - Desvarieux, Moise

AU - Engstrom, Gunnar

AU - Evans, Greg W.

AU - Hedblad, Bo

AU - Kauhanen, Jussi

AU - Kurl, Sudhir

AU - Lonn, Eva M.

AU - Mathiesen, Ellisiv B.

AU - Polak, Joseph F.

AU - Price, Jacqueline F.

AU - Rembold, Christopher M.

AU - Rosvall, Maria

AU - Rundek, Tatjana

AU - Salonen, Jukka T.

AU - Stehouwer, Coen

AU - Tuomainen, Tomi-Pekka

AU - Bots, Michiel L.

PY - 2017/7

Y1 - 2017/7

N2 - Epidemiological evidence indicates a protective effect of light to moderate alcohol consumption compared to non-drinking and heavy drinking. Although several mechanisms have been suggested, the effect of alcohol on atherosclerotic changes in vessel walls is unclear. Therefore, we explored the relationship between alcohol consumption and common carotid intima media thickness, a marker of early atherosclerosis in the general population.Individual participant data from eight cohorts, involving 37,494 individuals from the USE-IMT collaboration were used. Multilevel age and sex adjusted linear regression models were applied to estimate mean differences in common carotid intima-media thickness (CIMT) with alcohol consumption.The mean age was 57.9 years (SD 8.6) and the mean CIMT was 0.75 mm (SD 0.177). About, 40.5% reported no alcohol consumed, and among those who drank, mean consumption was 13.3 g per day (SD 16.4). Those consuming no alcohol or a very small amount (<5 g per day) had significantly lower common CIMT values than those consuming > 10 g per day, after adjusting for a range of confounding factors.In this large CIMT consortium, we did not find evidence to support a protective effect of alcohol on CIMT.

AB - Epidemiological evidence indicates a protective effect of light to moderate alcohol consumption compared to non-drinking and heavy drinking. Although several mechanisms have been suggested, the effect of alcohol on atherosclerotic changes in vessel walls is unclear. Therefore, we explored the relationship between alcohol consumption and common carotid intima media thickness, a marker of early atherosclerosis in the general population.Individual participant data from eight cohorts, involving 37,494 individuals from the USE-IMT collaboration were used. Multilevel age and sex adjusted linear regression models were applied to estimate mean differences in common carotid intima-media thickness (CIMT) with alcohol consumption.The mean age was 57.9 years (SD 8.6) and the mean CIMT was 0.75 mm (SD 0.177). About, 40.5% reported no alcohol consumed, and among those who drank, mean consumption was 13.3 g per day (SD 16.4). Those consuming no alcohol or a very small amount (<5 g per day) had significantly lower common CIMT values than those consuming > 10 g per day, after adjusting for a range of confounding factors.In this large CIMT consortium, we did not find evidence to support a protective effect of alcohol on CIMT.

KW - ARTERY STRUCTURE

KW - ATHEROSCLEROSIS

KW - RISK

KW - MODERATE

KW - ADULTS

KW - HEALTH

KW - OLDER

KW - METAANALYSIS

KW - ASSOCIATION

KW - BENEFITS

U2 - 10.1093/alcalc/agx028

DO - 10.1093/alcalc/agx028

M3 - Article

C2 - 28525540

SN - 0735-0414

VL - 52

SP - 483

EP - 486

JO - Alcohol and Alcoholism

JF - Alcohol and Alcoholism

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