Albumin Nanoparticle-Based Drug Delivery Systems

Na Qu, Ke Song, Yating Ji, Mingxia Liu, Lijiang Chen, Robert J. Lee, Lesheng Teng*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

Nanoparticle-based systems are extensively investigated for drug delivery. Among others, with superior biocompatibility and enhanced targeting capacity, albumin appears to be a promising carrier for drug delivery. Albumin nanoparticles are highly favored in many disease therapies, as they have the proper chemical groups for modification, cell-binding sites for cell adhesion, and affinity to protein drugs for nanocomplex generation. Herein, this review summarizes the recent fabrication techniques, modification strategies, and application of albumin nanoparticles. We first discuss various albumin nanoparticle fabrication methods, from both pros and cons. Then, we provide a comprehensive introduction to the modification section, including organic albumin nanoparticles, metal albumin nanoparticles, inorganic albumin nanoparticles, and albumin nanoparticle-based hybrids. We finally bring further perspectives on albumin nanoparticles used for various critical diseases. Plain Language Summary: Albumin appears to be a promising carrier for drug delivery with superior biocompatibility and enhanced targeting capacity. This review focuses on the importance of albumin nanoparticles in drug delivery and concludes the recent fabrication techniques to prepare albumin nanoparticles, the modification strategies to require functional albumin nanoparticles, and critical applications of albumin nanoparticles in various diseases. The aim of this review is to help readers understand the significant potential of albumin nanoparticles in drug delivery.
Original languageEnglish
Pages (from-to)6945-6980
Number of pages36
JournalInternational Journal of Nanomedicine
Volume19
DOIs
Publication statusPublished - 2024

Keywords

  • albumin nanoparticle
  • drug delivery
  • fabrication
  • modification
  • application
  • HUMAN SERUM-ALBUMIN
  • ENDOTHELIAL GROWTH-FACTOR
  • IN-VITRO
  • GOLD NANOPARTICLES
  • HYALURONIC-ACID
  • PROTEIN NANOPARTICLES
  • SILVER NANOPARTICLES
  • LOADED NANOPARTICLES
  • TITANIUM SCAFFOLDS
  • TARGETED DELIVERY

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