TY - JOUR
T1 - Airway Angiopoietin-2 in Ventilated Very Preterm Infants: Association With Prenatal Factors and Neonatal Outcome
AU - Thomas, Wolfgang
AU - Seidenspinner, Silvia
AU - Kramer, Boris W.
AU - Wirbelauer, Johannes
AU - Kawczynska-Leda, Natalia
AU - Szymankiewicz, Marta
AU - Speer, Christian P.
PY - 2011/8
Y1 - 2011/8
N2 - Objective: Pulmonary angiogenesis is a prerequisite for lung development. Angiopoietin-2 (Ang2) destabilizes endothelial cells through its endothelial receptor TIE-2, enabling vascular sprouting. Ang1 stabilizes new blood vessels. Soluble TIE-2 (sTIE-2) modulates these effects. We hypothesized that histological funisitis is associated with alterations of Ang2 in airways and of the systemic angiopoietin-TIE-2 homeostasis in very low birth weight (VLBW) infants, contributing to pulmonary morbidity and mortality. Methods: We measured Ang2 in tracheobronchial aspirate fluid (TAF) of 42 VLBW
AB - Objective: Pulmonary angiogenesis is a prerequisite for lung development. Angiopoietin-2 (Ang2) destabilizes endothelial cells through its endothelial receptor TIE-2, enabling vascular sprouting. Ang1 stabilizes new blood vessels. Soluble TIE-2 (sTIE-2) modulates these effects. We hypothesized that histological funisitis is associated with alterations of Ang2 in airways and of the systemic angiopoietin-TIE-2 homeostasis in very low birth weight (VLBW) infants, contributing to pulmonary morbidity and mortality. Methods: We measured Ang2 in tracheobronchial aspirate fluid (TAF) of 42 VLBW
KW - bronchopulmonary dysplasia
KW - lung injury
KW - angiogenesis
KW - vascular endothelial growth factor
KW - small for gestational age infant
U2 - 10.1002/ppul.21435
DO - 10.1002/ppul.21435
M3 - Article
C2 - 21337734
SN - 8755-6863
VL - 46
SP - 777
EP - 784
JO - Pediatric Pulmonology
JF - Pediatric Pulmonology
IS - 8
ER -