Airway Angiopoietin-2 in Ventilated Very Preterm Infants: Association With Prenatal Factors and Neonatal Outcome

Wolfgang Thomas*, Silvia Seidenspinner, Boris W. Kramer, Johannes Wirbelauer, Natalia Kawczynska-Leda, Marta Szymankiewicz, Christian P. Speer

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Web of Science)


Objective: Pulmonary angiogenesis is a prerequisite for lung development. Angiopoietin-2 (Ang2) destabilizes endothelial cells through its endothelial receptor TIE-2, enabling vascular sprouting. Ang1 stabilizes new blood vessels. Soluble TIE-2 (sTIE-2) modulates these effects. We hypothesized that histological funisitis is associated with alterations of Ang2 in airways and of the systemic angiopoietin-TIE-2 homeostasis in very low birth weight (VLBW) infants, contributing to pulmonary morbidity and mortality. Methods: We measured Ang2 in tracheobronchial aspirate fluid (TAF) of 42 VLBW
Original languageEnglish
Pages (from-to)777-784
JournalPediatric Pulmonology
Issue number8
Publication statusPublished - Aug 2011


  • bronchopulmonary dysplasia
  • lung injury
  • angiogenesis
  • vascular endothelial growth factor
  • small for gestational age infant

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