Agonist-induced modulation of glycocalyx barrier properties in the microcirculation : role in blood volume recruitment and oxygen exchange in the heart

J. Brands

Research output: ThesisDoctoral ThesisInternal

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Abstract

This dissertation research studies the role of the glycocalyx, a gel layer on the inside of all blood vessels in the heart. The glycocalyx turns out to behave as a thick non-stick layer that prevents damaging parts to stick to the wall and as an extra space for blood when more oxygen needs to be transported from the blood to the heart. Temporary adjustments of this layer appear to positively influence the blood and oxygen supply, but when this layer is damaged, that does not happen. Repair of a damaged glycocalyx could in the future be a possible therapy for patients suffering from chest pain.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Vink, Hans, Supervisor
  • Spaan, J.A.E., Supervisor, External person
  • van Teeffelen, Jurgen, Advisor
Award date29 Oct 2010
Place of PublicationMaastricht
Publisher
Print ISBNs9789064644108
Publication statusPublished - 1 Jan 2010

Keywords

  • glycocalyx
  • blood vessels

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