Aggressive antihypertensive therapy based on hydrochlorothiazide candesartan or lisinopril as initial choice in hypertensive type II diabetic individuals effects on albumin excretion endothelial function and inflammation in a double-blind randomized cl

M.T. Schram, F.J. van Ittersum, A.M. Spoelstra-de Man, R.A.J.M. van Dijk, C.G. Schalkwijk, R.G. Ijzerman, J.W.R. Twisk, C.D.A. Stehouwer

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Abstract

We investigated the effects of aggressive antihypertensive therapy based on hydrochlorothiazide, candesartan or lisinopril on urinary albumin excretion, endothelial function and inflammatory activity in hypertensive type II diabetic individuals. A total of 70 hypertensive type II diabetic individuals were treated with three antihypertensive strategies in a randomized, double- blind, doubledummy design. Blood pressure was titrated to levels below 130/ 85 mmHg or a decrease in systolic pressure of 10% with a diastolic pressure below 85mmHg. After titration, patients were treated for 12 months. Mean blood pressures changed from 157/ 93, 151/ 94 and 149/ 93 at baseline to 135/ 80, 135/ 82 and 131/ 80 mmHg after titration in the hydrochlorothiazide ( n = 24), candesartan ( n = 24) and lisinopril ( n = 22) groups. About 70% reached target blood pressures. However, only 45% had blood pressures used.
Original languageEnglish
Pages (from-to)429-437
JournalJournal of Human Hypertension
Volume19
DOIs
Publication statusPublished - 1 Jan 2005

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