We investigated the effects of aggressive antihypertensive therapy based on hydrochlorothiazide, candesartan or lisinopril on urinary albumin excretion, endothelial function and inflammatory activity in hypertensive type II diabetic individuals. A total of 70 hypertensive type II diabetic individuals were treated with three antihypertensive strategies in a randomized, double- blind, doubledummy design. Blood pressure was titrated to levels below 130/ 85 mmHg or a decrease in systolic pressure of 10% with a diastolic pressure below 85mmHg. After titration, patients were treated for 12 months. Mean blood pressures changed from 157/ 93, 151/ 94 and 149/ 93 at baseline to 135/ 80, 135/ 82 and 131/ 80 mmHg after titration in the hydrochlorothiazide ( n = 24), candesartan ( n = 24) and lisinopril ( n = 22) groups. About 70% reached target blood pressures. However, only 45% had blood pressures used.
Schram, M. T., van Ittersum, F. J., Spoelstra-de Man, A. M., van Dijk, R. A. J. M., Schalkwijk, C. G., Ijzerman, R. G., Twisk, J. W. R., & Stehouwer, C. D. A. (2005). Aggressive antihypertensive therapy based on hydrochlorothiazide candesartan or lisinopril as initial choice in hypertensive type II diabetic individuals effects on albumin excretion endothelial function and inflammation in a double-blind randomized cl. Journal of Human Hypertension, 19, 429-437. https://doi.org/10.1038/sj.jhh.1001812