Age-Related Alterations in Cardiac Geometry in Formerly Preeclamptic Women and Healthy Parous Controls: An Explorative Study

Chahinda Ghossein-Doha*, Sander M. J. van Kuijk, Marc E. A. Spaanderman, Tammo Delhaas, Louis L. H. Peeters

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Introduction: Preeclamptic pregnancies induce concentric left ventricular hypertrophy instead of eccentric left ventricular hypertrophy as seen in healthy pregnancies. Although these differences persist for at least several months postpartum, the long-term fate of these changes is unknown. Objective: To explore the age-related changes in cardiovascular structure and function in formerly preeclamptic women relative to parous controls. Methods: A total of 20 formerly preeclamptic women and 8 parous controls underwent 2 echocardiograms at 1 and 14 years of postpartum. With the nonparametric Mann-Whitney U test and the Wilcoxon Signed Ranks test, we analyzed the between-group differences in cardiac structure and function at both time points and the time-related changes in these indices. Results: Left ventricular geometry and dimensions and systolic function were comparable in the 2 study groups at both time points. The age-related decline in E/A ratio and increase in intraventricular septum thickness were noted in both groups over time, without appreciable differences between groups. Conclusion: A history of preeclampsia does not affect the age-related cardiac remodeling over a period of 14 years.
Original languageEnglish
Pages (from-to)39-44
JournalReproductive Sciences
Issue number1
Publication statusPublished - Jan 2013


  • preeclampsia
  • cardiac aging
  • left ventricular geometry
  • premenopausal women

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