Age-graded reductions in quadriceps muscle strength and peak aerobic capacity in COPD

M.A. Spruit, F.M.E. Franssen, E.P.A. Rutten, S.S. Wagers, E.F.M. Wouters

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND: Reductions in quadriceps strength and peak aerobic capacity (VO2) in patients with chronic obstructive pulmonary disease (COPD) have been studied in relatively small samples over a short period. Moreover, results were not corrected for confounding variables, such as lean muscle mass, gender, and gas transfer capacity of the lungs. OBJECTIVES: To compare quadriceps muscle strength and peak V.O2 in women and men while stratifying for age and gas transfer capacity. We then corrected for lower-limb lean muscle mass to see whether and to what extent the age-graded reduction remained evident. METHODS: Retrospectively, data of 374 women and 593 men with COPD were analyzed: lung function, current drug therapy, quadriceps strength, peak V.O2, lower-limb lean muscle mass, and gas transfer capacity. RESULTS: Quadriceps strength and peak V.O2 were lower in older women and men with a gas transfer capacity of <50% predicted, also after adjustment for lower-limb lean muscle mass. Moreover, quadriceps strength and peak V.O2 were lower in older women and men with a gas transfer capacity of <50% predicted, also after adjustment for lower-limb lean muscle mass. Moreover, quadriceps strength and peak V.O2 were related to age in COPD, particularly in women and men with a gas transfer capacity of >50% predicted. Yet, counter to our hypothesis, lower-limb lean muscle mass did not show an age-graded reduction and, in turn, could not account for the relationship of age with quadriceps strength and peak V.O2. CONCLUSIONS: It is apparent that there is an age-graded reduction in skeletal muscle function in patients with COPD. Therefore, prevention of an age-graded decline in quadriceps muscle strength and peak V.O2 may need to become an outcome of pulmonary rehabilitation of patients with COPD.
Original languageEnglish
Pages (from-to)148-156
Number of pages9
JournalRevista Brasileira de Fisioterapia
Volume16
Issue number2
DOIs
Publication statusPublished - 1 Jan 2012

Keywords

  • Chronic obstructive pulmonary disease
  • lower-limb lean muscle mass
  • peak aerobic capacity
  • quadriceps muscle strength
  • isokinetic quadriceps peak torque
  • aging
  • OBSTRUCTIVE PULMONARY-DISEASE
  • VASTUS LATERALIS MUSCLE
  • FAT-FREE MASS
  • SKELETAL-MUSCLE
  • EXERCISE CAPACITY
  • BODY-COMPOSITION
  • LUNG-DISEASE
  • DAILY-LIFE
  • WEAKNESS
  • REHABILITATION

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