Age-Dependent Differences in Postprandial Bile-Acid Metabolism and the Role of the Gut Microbiome

Soumia Majait; Emma C E Meessen; Mark Davids; Youssef Chahid; Steven W Olde Damink; Frank G Schaap; Ellis Marleen Kemper; Max Nieuwdorp; Maarten R Soeters

doi:10.3390/microorganisms12040764

Age-Dependent Differences in Postprandial Bile-Acid Metabolism and the Role of the Gut Microbiome

Soumia Majait, Emma C E Meessen, Mark Davids, Youssef Chahid, Steven W Olde Damink, Frank G Schaap, Ellis Marleen Kemper, Max Nieuwdorp, Maarten R Soeters^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Ageing changes the impact of nutrition, whereby inflammation has been suggested to play a role in age-related disabilities such as diabetes and cardiovascular disease. The aim of this study was to investigate differences in postprandial bile-acid response and its effect on energy metabolism between young and elderly people. Nine young, healthy men and nine elderly, healthy men underwent a liquid mixed-meal test. Postprandial bile-acid levels, insulin, glucose, GLP-1, C4, FGF19 and lipids were measured. Appetite, body composition, energy expenditure and gut microbiome were also measured. The elderly population showed lower glycine conjugated CDCA and UDCA levels and higher abundances of , and , but lower food intake, decreased fat free mass and increased cholesterol levels. Aging is associated with changes in postprandial bile-acid composition and microbiome, diminished hunger and changes in body composition and lipid levels. Further studies are needed to determine if these changes may contribute to malnutrition and sarcopenia in elderly.

Original language	English
Article number	764
Number of pages	15
Journal	Microorganisms
Volume	12
Issue number	4
DOIs	https://doi.org/10.3390/microorganisms12040764
Publication status	Published - 10 Apr 2024

Keywords

anorexia of aging
bile acids
insulin resistance
malnutrition
postprandial
sarcopenia

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title = "Age-Dependent Differences in Postprandial Bile-Acid Metabolism and the Role of the Gut Microbiome",

abstract = "Ageing changes the impact of nutrition, whereby inflammation has been suggested to play a role in age-related disabilities such as diabetes and cardiovascular disease. The aim of this study was to investigate differences in postprandial bile-acid response and its effect on energy metabolism between young and elderly people. Nine young, healthy men and nine elderly, healthy men underwent a liquid mixed-meal test. Postprandial bile-acid levels, insulin, glucose, GLP-1, C4, FGF19 and lipids were measured. Appetite, body composition, energy expenditure and gut microbiome were also measured. The elderly population showed lower glycine conjugated CDCA and UDCA levels and higher abundances of , and , but lower food intake, decreased fat free mass and increased cholesterol levels. Aging is associated with changes in postprandial bile-acid composition and microbiome, diminished hunger and changes in body composition and lipid levels. Further studies are needed to determine if these changes may contribute to malnutrition and sarcopenia in elderly.",

keywords = "anorexia of aging, bile acids, insulin resistance, malnutrition, postprandial, sarcopenia",

author = "Soumia Majait and Meessen, {Emma C E} and Mark Davids and Youssef Chahid and {Olde Damink}, {Steven W} and Schaap, {Frank G} and Kemper, {Ellis Marleen} and Max Nieuwdorp and Soeters, {Maarten R}",

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doi = "10.3390/microorganisms12040764",

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AU - Majait, Soumia

AU - Meessen, Emma C E

AU - Davids, Mark

AU - Chahid, Youssef

AU - Olde Damink, Steven W

AU - Schaap, Frank G

AU - Kemper, Ellis Marleen

AU - Nieuwdorp, Max

AU - Soeters, Maarten R

PY - 2024/4/10

Y1 - 2024/4/10

N2 - Ageing changes the impact of nutrition, whereby inflammation has been suggested to play a role in age-related disabilities such as diabetes and cardiovascular disease. The aim of this study was to investigate differences in postprandial bile-acid response and its effect on energy metabolism between young and elderly people. Nine young, healthy men and nine elderly, healthy men underwent a liquid mixed-meal test. Postprandial bile-acid levels, insulin, glucose, GLP-1, C4, FGF19 and lipids were measured. Appetite, body composition, energy expenditure and gut microbiome were also measured. The elderly population showed lower glycine conjugated CDCA and UDCA levels and higher abundances of , and , but lower food intake, decreased fat free mass and increased cholesterol levels. Aging is associated with changes in postprandial bile-acid composition and microbiome, diminished hunger and changes in body composition and lipid levels. Further studies are needed to determine if these changes may contribute to malnutrition and sarcopenia in elderly.

AB - Ageing changes the impact of nutrition, whereby inflammation has been suggested to play a role in age-related disabilities such as diabetes and cardiovascular disease. The aim of this study was to investigate differences in postprandial bile-acid response and its effect on energy metabolism between young and elderly people. Nine young, healthy men and nine elderly, healthy men underwent a liquid mixed-meal test. Postprandial bile-acid levels, insulin, glucose, GLP-1, C4, FGF19 and lipids were measured. Appetite, body composition, energy expenditure and gut microbiome were also measured. The elderly population showed lower glycine conjugated CDCA and UDCA levels and higher abundances of , and , but lower food intake, decreased fat free mass and increased cholesterol levels. Aging is associated with changes in postprandial bile-acid composition and microbiome, diminished hunger and changes in body composition and lipid levels. Further studies are needed to determine if these changes may contribute to malnutrition and sarcopenia in elderly.

KW - anorexia of aging

KW - bile acids

KW - insulin resistance

KW - malnutrition

KW - postprandial

KW - sarcopenia

U2 - 10.3390/microorganisms12040764

DO - 10.3390/microorganisms12040764

M3 - Article

SN - 2076-2607

VL - 12

JO - Microorganisms

JF - Microorganisms

IS - 4

M1 - 764

ER -

Age-Dependent Differences in Postprandial Bile-Acid Metabolism and the Role of the Gut Microbiome

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Keywords

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