Age-dependent changes in GI physiology and microbiota: time to reconsider?

Ran An; Ellen Wilms; Ad A. M. Masclee; Hauke Smidt; Erwin G. Zoetendal; Daisy Jonkers

doi:10.1136/gutjnl-2017-315542

Age-dependent changes in GI physiology and microbiota: time to reconsider?

Ran An, Ellen Wilms, Ad A. M. Masclee, Hauke Smidt, Erwin G. Zoetendal^*, Daisy Jonkers

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Our life expectancy is increasing, leading to a rise in the ageing population. Ageing is associated with a decline in physiological function and adaptive capacity. Altered GI physiology can affect the amount and types of nutrients digested and absorbed as well as impact the intestinal microbiota. The intestinal microbiota is considered a key player in our health, and a variety of studies have reported that microbiota composition is changing during ageing. Since ageing is associated with a decline in GI function and adaptive capacity, it is crucial to obtain insights into this decline and how this is related to the intestinal microbiota in the elderly. Hence, in this review we focus on age-related changes in GI physiology and function, changes of the intestinal microbiota with ageing and frailty, how these are associated and how intestinal microbiota-targeted interventions may counteract these changes.

Original language	English
Pages (from-to)	2213-2222
Number of pages	10
Journal	Gut
Volume	67
Issue number	12
DOIs	https://doi.org/10.1136/gutjnl-2017-315542
Publication status	Published - Dec 2018

Keywords

NONSTEROIDAL ANTIINFLAMMATORY DRUGS
GUT MICROBIOTA
FECAL MICROBIOTA
INTESTINAL MICROBIOTA
YOUNG-ADULTS
OLDER ADULTS
FRAILTY
PREVALENCE
HEALTH
DIET

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title = "Age-dependent changes in GI physiology and microbiota: time to reconsider?",

abstract = "Our life expectancy is increasing, leading to a rise in the ageing population. Ageing is associated with a decline in physiological function and adaptive capacity. Altered GI physiology can affect the amount and types of nutrients digested and absorbed as well as impact the intestinal microbiota. The intestinal microbiota is considered a key player in our health, and a variety of studies have reported that microbiota composition is changing during ageing. Since ageing is associated with a decline in GI function and adaptive capacity, it is crucial to obtain insights into this decline and how this is related to the intestinal microbiota in the elderly. Hence, in this review we focus on age-related changes in GI physiology and function, changes of the intestinal microbiota with ageing and frailty, how these are associated and how intestinal microbiota-targeted interventions may counteract these changes.",

keywords = "NONSTEROIDAL ANTIINFLAMMATORY DRUGS, GUT MICROBIOTA, FECAL MICROBIOTA, INTESTINAL MICROBIOTA, YOUNG-ADULTS, OLDER ADULTS, FRAILTY, PREVALENCE, HEALTH, DIET",

author = "Ran An and Ellen Wilms and Masclee, {Ad A. M.} and Hauke Smidt and Zoetendal, {Erwin G.} and Daisy Jonkers",

year = "2018",

month = dec,

doi = "10.1136/gutjnl-2017-315542",

language = "English",

volume = "67",

pages = "2213--2222",

journal = "Gut",

issn = "0017-5749",

publisher = "BMJ Publishing Group",

number = "12",

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TY - JOUR

T1 - Age-dependent changes in GI physiology and microbiota

T2 - time to reconsider?

AU - An, Ran

AU - Wilms, Ellen

AU - Masclee, Ad A. M.

AU - Smidt, Hauke

AU - Zoetendal, Erwin G.

AU - Jonkers, Daisy

PY - 2018/12

Y1 - 2018/12

N2 - Our life expectancy is increasing, leading to a rise in the ageing population. Ageing is associated with a decline in physiological function and adaptive capacity. Altered GI physiology can affect the amount and types of nutrients digested and absorbed as well as impact the intestinal microbiota. The intestinal microbiota is considered a key player in our health, and a variety of studies have reported that microbiota composition is changing during ageing. Since ageing is associated with a decline in GI function and adaptive capacity, it is crucial to obtain insights into this decline and how this is related to the intestinal microbiota in the elderly. Hence, in this review we focus on age-related changes in GI physiology and function, changes of the intestinal microbiota with ageing and frailty, how these are associated and how intestinal microbiota-targeted interventions may counteract these changes.

AB - Our life expectancy is increasing, leading to a rise in the ageing population. Ageing is associated with a decline in physiological function and adaptive capacity. Altered GI physiology can affect the amount and types of nutrients digested and absorbed as well as impact the intestinal microbiota. The intestinal microbiota is considered a key player in our health, and a variety of studies have reported that microbiota composition is changing during ageing. Since ageing is associated with a decline in GI function and adaptive capacity, it is crucial to obtain insights into this decline and how this is related to the intestinal microbiota in the elderly. Hence, in this review we focus on age-related changes in GI physiology and function, changes of the intestinal microbiota with ageing and frailty, how these are associated and how intestinal microbiota-targeted interventions may counteract these changes.

KW - NONSTEROIDAL ANTIINFLAMMATORY DRUGS

KW - GUT MICROBIOTA

KW - FECAL MICROBIOTA

KW - INTESTINAL MICROBIOTA

KW - YOUNG-ADULTS

KW - OLDER ADULTS

KW - FRAILTY

KW - PREVALENCE

KW - HEALTH

KW - DIET

U2 - 10.1136/gutjnl-2017-315542

DO - 10.1136/gutjnl-2017-315542

M3 - Article

SN - 0017-5749

VL - 67

SP - 2213

EP - 2222

JO - Gut

JF - Gut

IS - 12

ER -

Age-dependent changes in GI physiology and microbiota: time to reconsider?

Abstract

Keywords

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