Age at Onset of Psychotic Disorder: Cannabis, BDNF Val66Met, and Sex-Specific Models of Gene-Environment Interaction

Jeroen Decoster; Jim van Os; Gunter Kenis; Charles Henquet; Joseph Peuskens; Marc De Hert; Ruud van Winkel

doi:10.1002/ajmg.b.31174

Age at Onset of Psychotic Disorder: Cannabis, BDNF Val66Met, and Sex-Specific Models of Gene-Environment Interaction

Jeroen Decoster
, Jim van Os
, Gunter Kenis
, Charles Henquet
, Joseph Peuskens
, Marc De Hert
, Ruud van Winkel^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Discovering modifiable predictors for age at onset may help to identify predictors of transition to psychotic disorder in the "atrisk mental state." Inconsistent effects of sex, BDNF Val66Met (rs6265), and cannabis use on age of onset were previously reported. BDNF Val66Met and cannabis use before illness onset were retrospectively assessed in a sample of 585 patients with schizophrenia and their association with age at onset was evaluated. Cannabis use was significantly associated with earlier age at onset of psychotic disorder (AOP; average difference 2.7 years, P

Original language	English
Pages (from-to)	363-369
Number of pages	7
Journal	American Journal of Medical Genetics Part B-neuropsychiatric Genetics
Volume	156B
Issue number	3
DOIs	https://doi.org/10.1002/ajmg.b.31174
Publication status	Published - Apr 2011

Keywords

schizophrenia
tetrahydrocannabinol (THC)
neurotrophins
gender

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AU - Decoster, Jeroen

AU - van Os, Jim

AU - Kenis, Gunter

AU - Henquet, Charles

AU - Peuskens, Joseph

AU - De Hert, Marc

AU - van Winkel, Ruud

PY - 2011/4

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AB - Discovering modifiable predictors for age at onset may help to identify predictors of transition to psychotic disorder in the "atrisk mental state." Inconsistent effects of sex, BDNF Val66Met (rs6265), and cannabis use on age of onset were previously reported. BDNF Val66Met and cannabis use before illness onset were retrospectively assessed in a sample of 585 patients with schizophrenia and their association with age at onset was evaluated. Cannabis use was significantly associated with earlier age at onset of psychotic disorder (AOP; average difference 2.7 years, P

KW - schizophrenia

KW - tetrahydrocannabinol (THC)

KW - neurotrophins

KW - gender

U2 - 10.1002/ajmg.b.31174

DO - 10.1002/ajmg.b.31174

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JO - American Journal of Medical Genetics Part B-neuropsychiatric Genetics

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IS - 3

ER -

Age at Onset of Psychotic Disorder: Cannabis, BDNF Val66Met, and Sex-Specific Models of Gene-Environment Interaction

Abstract

Keywords

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