Abstract
Discovering modifiable predictors for age at onset may help to identify predictors of transition to psychotic disorder in the "atrisk mental state." Inconsistent effects of sex, BDNF Val66Met (rs6265), and cannabis use on age of onset were previously reported. BDNF Val66Met and cannabis use before illness onset were retrospectively assessed in a sample of 585 patients with schizophrenia and their association with age at onset was evaluated. Cannabis use was significantly associated with earlier age at onset of psychotic disorder (AOP; average difference 2.7 years, P
Original language | English |
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Pages (from-to) | 363-369 |
Journal | American Journal of Medical Genetics Part B-neuropsychiatric Genetics |
Volume | 156B |
Issue number | 3 |
DOIs | |
Publication status | Published - Apr 2011 |
Keywords
- schizophrenia
- tetrahydrocannabinol (THC)
- neurotrophins
- gender