Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population

V. Paquin; L.K. Pries; M. ten Have; M. Bak; N. Gunther; R. de Graaf; S. van Dorsselaer; B.C.D. Lin; K.R. van Eijk; G. Kenis; A. Richards; M.C. O'Donovan; J.J. Luykx; B.P.F. Rutten; J. van Os; J.L. Shah; S. Guloksuz

doi:10.1007/s00127-022-02346-3

Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population

V. Paquin, L.K. Pries, M. ten Have, M. Bak, N. Gunther, R. de Graaf, S. van Dorsselaer, B.C.D. Lin, K.R. van Eijk, G. Kenis, A. Richards, M.C. O'Donovan, J.J. Luykx, B.P.F. Rutten, J. van Os, J.L. Shah, S. Guloksuz^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Purpose The health correlates of polygenic risk (PRS-SCZ) and exposome (ES-SCZ) scores for schizophrenia may vary depending on age and sex. We aimed to examine age- and sex-specific associations of PRS-SCZ and ES-SCZ with self-reported health in the general population. Methods Participants were from the population-based Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2). Mental and physical health were measured with the 36-item Short Form Survey 4 times between 2007 and 2018. The PRS-SCZ and ES-SCZ were respectively calculated from common genetic variants and exposures (cannabis use, winter birth, hearing impairment, and five childhood adversity categories). Moderation by age and sex was examined in linear mixed models. Results For PRS-SCZ and ES-SCZ analyses, we included 3099 and 6264 participants, respectively (age range 18-65 years; 55.7-56.1% female). Age and sex did not interact with PRS-SCZ. Age moderated the association between ES-SCZ and mental (interaction: p = 0.02) and physical health (p = 0.0007): at age 18, + 1.00 of ES-SCZ was associated with - 0.10 of mental health and - 0.08 of physical health, whereas at age 65, it was associated with - 0.21 and - 0.23, respectively (all units in standard deviations). Sex moderated the association between ES-SCZ and physical health (p < .0001): + 1.00 of ES-SCZ was associated with - 0.19 of physical health among female and - 0.11 among male individuals. Conclusion There were larger associations between higher ES-SCZ and poorer health among female and older individuals. Accounting for these interactions may increase ES-SCZ precision and help uncover populational determinants of environmental influences on health.

Original language	English
Pages (from-to)	43-52
Number of pages	10
Journal	Social Psychiatry and Psychiatric Epidemiology
Volume	58
Issue number	1
Early online date	1 Aug 2022
DOIs	https://doi.org/10.1007/s00127-022-02346-3
Publication status	Published - Jan 2023

Keywords

Exposome
Genes
Schizophrenia
Quality of life
Sex characteristics
POLYGENIC RISK
CHILDHOOD
ONSET
TWIN

Access to Document

10.1007/s00127-022-02346-3Licence: CC BY

Cite this

Paquin, V., Pries, L. K., ten Have, M., Bak, M., Gunther, N., de Graaf, R., van Dorsselaer, S., Lin, B. C. D., van Eijk, K. R., Kenis, G., Richards, A., O'Donovan, M. C., Luykx, J. J., Rutten, B. P. F., van Os, J., Shah, J. L., & Guloksuz, S. (2023). Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population. Social Psychiatry and Psychiatric Epidemiology, 58(1), 43-52. https://doi.org/10.1007/s00127-022-02346-3

@article{30b203f7361e4d3ebd84ec5f3c02074e,

title = "Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population",

abstract = "Purpose The health correlates of polygenic risk (PRS-SCZ) and exposome (ES-SCZ) scores for schizophrenia may vary depending on age and sex. We aimed to examine age- and sex-specific associations of PRS-SCZ and ES-SCZ with self-reported health in the general population. Methods Participants were from the population-based Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2). Mental and physical health were measured with the 36-item Short Form Survey 4 times between 2007 and 2018. The PRS-SCZ and ES-SCZ were respectively calculated from common genetic variants and exposures (cannabis use, winter birth, hearing impairment, and five childhood adversity categories). Moderation by age and sex was examined in linear mixed models. Results For PRS-SCZ and ES-SCZ analyses, we included 3099 and 6264 participants, respectively (age range 18-65 years; 55.7-56.1% female). Age and sex did not interact with PRS-SCZ. Age moderated the association between ES-SCZ and mental (interaction: p = 0.02) and physical health (p = 0.0007): at age 18, + 1.00 of ES-SCZ was associated with - 0.10 of mental health and - 0.08 of physical health, whereas at age 65, it was associated with - 0.21 and - 0.23, respectively (all units in standard deviations). Sex moderated the association between ES-SCZ and physical health (p < .0001): + 1.00 of ES-SCZ was associated with - 0.19 of physical health among female and - 0.11 among male individuals. Conclusion There were larger associations between higher ES-SCZ and poorer health among female and older individuals. Accounting for these interactions may increase ES-SCZ precision and help uncover populational determinants of environmental influences on health.",

keywords = "Exposome, Genes, Schizophrenia, Quality of life, Sex characteristics, POLYGENIC RISK, CHILDHOOD, ONSET, TWIN",

author = "V. Paquin and L.K. Pries and {ten Have}, M. and M. Bak and N. Gunther and {de Graaf}, R. and {van Dorsselaer}, S. and B.C.D. Lin and {van Eijk}, K.R. and G. Kenis and A. Richards and M.C. O'Donovan and J.J. Luykx and B.P.F. Rutten and {van Os}, J. and J.L. Shah and S. Guloksuz",

note = "Funding Information: M.O. is supported by a collaborative research grant from Takeda Pharmaceuticals. Takeda played no part in the conception, design, implementation, funding or interpretation of this paper. No other disclosures were reported. Funding Information: NEMESIS-2 is conducted by the Netherlands Institute of Mental Health and Addiction (Trimbos Institute) in Utrecht. The funder had no role in the design and conduct. Financial support has been received from the Ministry of Health, Welfare and Sport, with supplementary support from the Netherlands Organization for Health Research and Development (ZonMw). This work was supported by the European Community{\textquoteright}s Seventh Framework Program under grant agreement No. HEALTH-F2-2009-241909 (Project EU-GEI). These funding sources had no further role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication. B.P.F.R. was funded by a VIDI award number 91718336 from the Netherlands Scientific Organisation. S.G. and J.v.O. are supported by the Ophelia research project, ZonMw grant number: 636340001. M.O. is supported by MRC programme grant (G08005009) and an MRC Centre grant (MR/L010305/1). Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2023",

month = jan,

doi = "10.1007/s00127-022-02346-3",

language = "English",

volume = "58",

pages = "43--52",

journal = "Social Psychiatry and Psychiatric Epidemiology",

issn = "0933-7954",

publisher = "Springer",

number = "1",

}

Paquin, V, Pries, LK, ten Have, M, Bak, M, Gunther, N, de Graaf, R, van Dorsselaer, S, Lin, BCD, van Eijk, KR, Kenis, G, Richards, A, O'Donovan, MC, Luykx, JJ, Rutten, BPF, van Os, J, Shah, JL & Guloksuz, S 2023, 'Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population', Social Psychiatry and Psychiatric Epidemiology, vol. 58, no. 1, pp. 43-52. https://doi.org/10.1007/s00127-022-02346-3

TY - JOUR

T1 - Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population

AU - Paquin, V.

AU - Pries, L.K.

AU - ten Have, M.

AU - Bak, M.

AU - Gunther, N.

AU - de Graaf, R.

AU - van Dorsselaer, S.

AU - Lin, B.C.D.

AU - van Eijk, K.R.

AU - Kenis, G.

AU - Richards, A.

AU - O'Donovan, M.C.

AU - Luykx, J.J.

AU - Rutten, B.P.F.

AU - van Os, J.

AU - Shah, J.L.

AU - Guloksuz, S.

N1 - Funding Information: M.O. is supported by a collaborative research grant from Takeda Pharmaceuticals. Takeda played no part in the conception, design, implementation, funding or interpretation of this paper. No other disclosures were reported. Funding Information: NEMESIS-2 is conducted by the Netherlands Institute of Mental Health and Addiction (Trimbos Institute) in Utrecht. The funder had no role in the design and conduct. Financial support has been received from the Ministry of Health, Welfare and Sport, with supplementary support from the Netherlands Organization for Health Research and Development (ZonMw). This work was supported by the European Community’s Seventh Framework Program under grant agreement No. HEALTH-F2-2009-241909 (Project EU-GEI). These funding sources had no further role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication. B.P.F.R. was funded by a VIDI award number 91718336 from the Netherlands Scientific Organisation. S.G. and J.v.O. are supported by the Ophelia research project, ZonMw grant number: 636340001. M.O. is supported by MRC programme grant (G08005009) and an MRC Centre grant (MR/L010305/1). Publisher Copyright: © 2022, The Author(s).

PY - 2023/1

Y1 - 2023/1

N2 - Purpose The health correlates of polygenic risk (PRS-SCZ) and exposome (ES-SCZ) scores for schizophrenia may vary depending on age and sex. We aimed to examine age- and sex-specific associations of PRS-SCZ and ES-SCZ with self-reported health in the general population. Methods Participants were from the population-based Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2). Mental and physical health were measured with the 36-item Short Form Survey 4 times between 2007 and 2018. The PRS-SCZ and ES-SCZ were respectively calculated from common genetic variants and exposures (cannabis use, winter birth, hearing impairment, and five childhood adversity categories). Moderation by age and sex was examined in linear mixed models. Results For PRS-SCZ and ES-SCZ analyses, we included 3099 and 6264 participants, respectively (age range 18-65 years; 55.7-56.1% female). Age and sex did not interact with PRS-SCZ. Age moderated the association between ES-SCZ and mental (interaction: p = 0.02) and physical health (p = 0.0007): at age 18, + 1.00 of ES-SCZ was associated with - 0.10 of mental health and - 0.08 of physical health, whereas at age 65, it was associated with - 0.21 and - 0.23, respectively (all units in standard deviations). Sex moderated the association between ES-SCZ and physical health (p < .0001): + 1.00 of ES-SCZ was associated with - 0.19 of physical health among female and - 0.11 among male individuals. Conclusion There were larger associations between higher ES-SCZ and poorer health among female and older individuals. Accounting for these interactions may increase ES-SCZ precision and help uncover populational determinants of environmental influences on health.

AB - Purpose The health correlates of polygenic risk (PRS-SCZ) and exposome (ES-SCZ) scores for schizophrenia may vary depending on age and sex. We aimed to examine age- and sex-specific associations of PRS-SCZ and ES-SCZ with self-reported health in the general population. Methods Participants were from the population-based Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2). Mental and physical health were measured with the 36-item Short Form Survey 4 times between 2007 and 2018. The PRS-SCZ and ES-SCZ were respectively calculated from common genetic variants and exposures (cannabis use, winter birth, hearing impairment, and five childhood adversity categories). Moderation by age and sex was examined in linear mixed models. Results For PRS-SCZ and ES-SCZ analyses, we included 3099 and 6264 participants, respectively (age range 18-65 years; 55.7-56.1% female). Age and sex did not interact with PRS-SCZ. Age moderated the association between ES-SCZ and mental (interaction: p = 0.02) and physical health (p = 0.0007): at age 18, + 1.00 of ES-SCZ was associated with - 0.10 of mental health and - 0.08 of physical health, whereas at age 65, it was associated with - 0.21 and - 0.23, respectively (all units in standard deviations). Sex moderated the association between ES-SCZ and physical health (p < .0001): + 1.00 of ES-SCZ was associated with - 0.19 of physical health among female and - 0.11 among male individuals. Conclusion There were larger associations between higher ES-SCZ and poorer health among female and older individuals. Accounting for these interactions may increase ES-SCZ precision and help uncover populational determinants of environmental influences on health.

KW - Exposome

KW - Genes

KW - Schizophrenia

KW - Quality of life

KW - Sex characteristics

KW - POLYGENIC RISK

KW - CHILDHOOD

KW - ONSET

KW - TWIN

U2 - 10.1007/s00127-022-02346-3

DO - 10.1007/s00127-022-02346-3

M3 - Article

C2 - 35913550

SN - 0933-7954

VL - 58

SP - 43

EP - 52

JO - Social Psychiatry and Psychiatric Epidemiology

JF - Social Psychiatry and Psychiatric Epidemiology

IS - 1

ER -

Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population

Abstract

Keywords

Access to Document

Fingerprint

Cite this