Affective symptoms and AT(N) biomarkers in mild cognitive impairment and Alzheimer's disease: A systematic literature review

Research output: Contribution to journal(Systematic) Review article peer-review

22 Citations (Web of Science)

Abstract

Introduction: Alzheimer's disease (AD) biomarkers such as amyloid, p-tau and neuronal injury markers have been associated with affective symptoms in cognitively impaired individuals, but results are conflicting.

Methods: CINAHL, Embase, PsycINFO and PubMed were searched for studies evaluating AD biomarkers with affective symptoms in mild cognitive impairment and AD dementia. Studies were classified according to AT(N) research criteria.

Result: Forty-five abstracts fulfilled eligibility criteria, including in total 8,293 patients (41 cross-sectional studies and 7 longitudinal studies). Depression and night-time behaviour disturbances were not related to AT(N) markers. Apathy was associated with A markers (PET, not CSF). Mixed findings were reported for the association between apathy and T(N) markers; anxiety and AT(N) markers; and between agitation and irritability and A markers. Agitation and irritability were not associated with T(N) markers.

Discussion: Whereas some AD biomarkers showed to be associated with affective symptoms in AD, most evidence was inconsistent. This is likely due to differences in study design or heterogeneity in affective symptoms. Directions for future research are given.

Original languageEnglish
Pages (from-to)346-359
Number of pages14
JournalNeuroscience and Biobehavioral Reviews
Volume107
DOIs
Publication statusPublished - Dec 2019

Keywords

  • Affective symptoms
  • Biomarkers
  • Neurocognitive disorders
  • Mild cognitive impairment
  • Alzheimer's disease dementia
  • Systematic review
  • WHITE-MATTER HYPERINTENSITIES
  • CEREBROSPINAL-FLUID BIOMARKERS
  • TEMPORAL-LOBE ATROPHY
  • QUALITY-OF-LIFE
  • DEPRESSIVE SYMPTOMS
  • NEUROPSYCHIATRIC SYMPTOMS
  • HIPPOCAMPAL VOLUME
  • ANXIETY SYMPTOMS
  • CSF BIOMARKERS
  • EARLY-STAGE

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