Affective and psychotic reactivity to daily-life stress in adults with 22q11DS: a study using the experience sampling method

Maude Schneider*, Thomas Vaessen, Esther D. A. van Duin, Zuzana Kasanova, Wolfgang Viechtbauer, Ulrich Reininghaus, Claudia Vingerhoets, Jan Booij, Ann Swillen, Jacob A. S. Vorstman, Therese van Amelsvoort, Inez Myin-Germeys

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Web of Science)

Abstract

Background 22q11.2 deletion syndrome (22q11DS) is a genetic disorder associated with an increased risk of psychiatric disorders. Vulnerability for psychopathology has been related to an increased reactivity to stress. Here, we examined affective states, perceived stress, affective and psychotic reactivity to various sources of environmental stress using the experience sampling method (ESM), a structured diary technique allowing repeated assessments in the context of daily life. Methods Adults with 22q11DS (n = 31; age, 34.1 years) and matched healthy controls (HCs; n = 24; age, 39.9 years) were included. ESM was used to assess affective states, perceived stress, and stress reactivity. Data were analyzed using multilevel regression models. Results Adults with 22q11DS displayed overall higher levels of negative affect but comparable levels of positive affect compared to HCs. Higher levels of perceived stress were reported by individuals with 22q11DS. Comparable affective and psychotic reactivity in relation to all types of environmental stress was observed between the two groups. Conclusion The results point toward higher levels of negative affect and differences in the perception of daily hassles in 22q11DS but no difference in affective or psychotic reactivity to stress. This study contributes to the growing literature regarding the impact of stress on the development of psychopathology in the 22q11DS population.

Original languageEnglish
Article number30
Number of pages11
JournalJournal of Neurodevelopmental Disorders
Volume12
Issue number1
DOIs
Publication statusPublished - 13 Nov 2020

Keywords

  • Experience sampling method
  • 22q11
  • 2 deletion syndrome
  • Stress reactivity
  • Positive affect
  • Negative affect
  • Momentary psychotic experiences
  • CHILDHOOD ADVERSITIES
  • DELETION SYNDROME
  • PSYCHIATRIC-DISORDERS
  • EMOTIONAL REACTIVITY
  • MEMORY IMPAIRMENTS
  • RISK
  • PSYCHOPATHOLOGY
  • SCHIZOPHRENIA
  • METAANALYSIS
  • INTERVIEW

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