Advancing the cell culture landscape: the instructive potential of artificial and natural geometries

Research output: ThesisDoctoral ThesisInternal

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This research focuses on how surface structures can influence the behaviour of cells. There is a great diversity of surface structures, which makes the identification of an optimal physical environment for a specific phenotype difficult. Therefore, platforms that allow screening of many different designs at the same time facilitate the identification of an optimal cultural environment. Using the TopoChip, which contains 2176 unique microtopographies, structures have been identified that support the tenocyte phenotype, the primary cell type of the tendon. In addition, this also applies to mesenchymal stem cells (MSCs), which experience an activation of tendon-related genes. Furthermore, the library has been creatively expanded by using natural surface topographies that cause unique cell behaviour, such as promoting osteogenesis.
Original languageEnglish
Awarding Institution
  • Maastricht University
  • de Boer, Jan, Supervisor, External person
  • Carlier, Aurélie, Co-Supervisor
Award date4 Sept 2020
Place of PublicationMaastricht
Print ISBNs9789463808866
Publication statusPublished - 2020


  • cell culture
  • physical cues
  • mechanobiology
  • cell phenotype
  • regenerative medicine

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