Advances in the role of sacral nerve neuromodulation in lower urinary tract symptoms

Philip E. V. A. Van Kerrebroeck*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Web of Science)


Sacral neuromodulation has been developed to treat chronic lower urinary tract symptoms, resistant to classical conservative therapy. The suspected mechanisms of action include afferent stimulation of the central nervous system and modulation of activity at the level of the brain. Typical neuromodulation is indicated both in overactivity and in underactivity of the lower urinary tract. In the majority of patients, a unilateral electrode in a sacral foramen and connected to a pulse generator is sufficient to achieve significant clinical results also on long term. In recent years, other urological indications have been explored.
Original languageEnglish
Pages (from-to)467-474
JournalInternational Urogynecology Journal
Issue numberS2
Publication statusPublished - Dec 2010


  • Lower urinary tract symptoms (LUTS)
  • Sacral neuromodulation
  • Bladder pacemaker

Cite this